RESUMEN
Extraskeletal Ewing's sarcoma arising in the head and neck region is an extremely rare malignant neoplasm. We describe the unusual case of a tumor originating in the larynx of a 68-year-old male with hoarseness and occasional aphonia. We report successful treatment with sequential chemo- and radiotherapy. Complete regression and larynx preservation with voice function recovery was achieved. To our knowledge, this is the first report of this type of tumor in the larynx with cartilage invasion that documents the effectiveness of radiotherapy as an alternative to surgical management. At present, after 30 months of follow-up, the patient is free of tumor relapse and in very good condition.
Asunto(s)
Neoplasias Laríngeas/tratamiento farmacológico , Neoplasias Laríngeas/radioterapia , Tratamientos Conservadores del Órgano/métodos , Sarcoma de Ewing/tratamiento farmacológico , Sarcoma de Ewing/radioterapia , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Afonía/etiología , Biomarcadores de Tumor/análisis , Biopsia , Quimioterapia Adyuvante , Terapia Combinada , Ronquera/etiología , Humanos , Cartílagos Laríngeos/patología , Neoplasias Laríngeas/patología , Laringoscopía , Laringe/patología , Masculino , Invasividad Neoplásica , Estadificación de Neoplasias , Tomografía de Emisión de Positrones , Sarcoma de Ewing/patología , Tomografía Computarizada por Rayos X , Pliegues Vocales/patologíaRESUMEN
Fine needle aspiration (FNA) is routine diagnostic tool in breast tumors assessment. In some cases, however, limitations of this method do not permit an unequivocal diagnosis. In these, suspected, cases immunocytochemical evaluation of selected biological markers may be of help. The aim of the study was assessment of HSP27 value in diagnosis and discrimination of benign and malignant breast lesions. HSP27 expression was examined by immunocytochemistry in fine needle aspiration smears assessed to C2-C5 categories. In C5 subgroup HSP27 expression was correlated with ER, PR content. Statistically significant differences in HSP27 expression between subsets C2/C5 and C3/C5 were found (p=0.028 and p=0,04, respectively); the differences between C3/C4 categories were not significant. Expression of HSP27 protein in FNA smears can be additional factor, which helps to differentiate benign, and malignant breast lesions, however it is not useful for discrimination of cytological, suspicious lesions.