Identification by electron spin resonance spectroscopy of free radicals produced during autoxidative melanogenesis.

Free radicals produced during the autoxidation of 3,4-dihydroxyphenylalanine (DOPA) and other catechol(amine)s to melanins have been studied using electron spin resonance spectroscopy. Magnetic parameters for the radical intermediates have been determined, allowing the radicals to be unambiguously identified. Three types of radical are formed: the primary radical from one-electron oxidation of the parent catechol(amine); and two secondary radicals, one formed via OH- substitution, the other via cyclization. The formation of these radical species can be linked to molecular products formed during catecholamine oxidation and melanin formation.

[Autoimmune thrombocytopenia in pregnant women: diagnosis, treatment and prevention of complications in children]. / Autoimmunologiczna maloplytkowosc u kobiet w ciazy: rozpoznawanie, leczenie, zapobieganie powiklaniom u dzieci.

9 pregnancies (in 6 women) complicated by autoimmune thrombocytopenia were studied. Corticosteroids and/or azathioprine and/or intravenous immunoglobulins (IgG i.v.) were administered to 5 women during pregnancy. 1 complete remission (CR) was achieved after 3 mo. of treatment by corticosteroids and azathioprine. In peripartum period the treatment was administered in 7 cases (corticosteroids, IgG i.v., platelet transfusion). There were no haemorrhagic complications during peripartum period (8 vaginal delivery, 1 cesarean section). In 3 of 5 examined cases IgG antiplatelet antibody was detected. Study group was to small to define the correlation between level of antiplatelet antibodies and neonatal thrombocytopenia. 10 infants were born. 4 infants (including siblings) were found to have normal platelet counts immediately after delivery. They mothers were treated by IgG i.v. in 2 cases and 1 women in CR at the time of delivery. 4 infants were thrombocytopenic but required no treatment. Duration time of thrombocytopenia was 1 to 4 weeks. In these cases mothers were treated only by corticosteroids or had no therapy.

[Pregnancy and labor in patients with idiopathic thrombocytopenia-- analysis of 12 cases]. / Ciaza i poród u pacjentek z maloplytkowoscia samoistna--analiza 12 przypadków.

The management is described of 12 pregnant patients with idiopathic thrombocytopenia. In no case perinatal haemorrhage developed. All labor took place through the genital canal. No perinatal injuries were observed in the newborns.