1.
J Org Chem
; 87(22): 15380-15388, 2022 Nov 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36317961
RESUMEN
A simple protocol for the noble-metal-free oxidative cyclization of enamines and tBuONO has been developed. This KI-mediated formal [4 + 1] cycloamination reaction provides a practical strategy for the synthesis of imidazole-4-carboxylic derivatives using tBuONO both as an aminating reagent and oxidant. The reaction features wide substrate scope and good functional tolerance for enamine compounds, even the unactivated ones.