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1.
Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease.
J Lipid Res
; 61(8): 1192-1202, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32482718
2.
Selective Activation of AMPK ß1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J Pharmacol Exp Ther
; 361(2): 303-311, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28289077
3.
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Biochem J
; 473(5): 581-92, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26635351
4.
Development of a selective activity-based probe for glycosylated LIPA.
Bioorg Med Chem Lett
; 26(8): 1993-6, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26965858
5.
Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype.
Protein Expr Purif
; 110: 22-9, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25620107
6.
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem J
; 460(2): 211-22, 2014 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24593284
7.
Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase.
J Biol Chem
; 287(10): 7717-27, 2012 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-22219190
8.
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
Proc Natl Acad Sci U S A
; 107(34): 15240-5, 2010 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20696890
9.
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun
; 14(1): 5938, 2023 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37741852
10.
Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
J Biol Chem
; 286(48): 41510-41519, 2011 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-21953464
11.
Initiation of translation at an upstream non-AUG codon accounting for N-terminally extended minor forms of recombinant proteins expressed in insect cells.
Protein Expr Purif
; 76(1): 72-8, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20888915
12.
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
Hepatology
; 49(2): 598-607, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19085960
13.
Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.
Protein Expr Purif
; 73(2): 189-97, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20451617
14.
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorg Med Chem Lett
; 20(7): 2383-8, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20219367
15.
Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.
J Pharmacol Exp Ther
; 330(2): 430-9, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19458106
16.
Synthesis and structure based optimization of novel Akt inhibitors.
Bioorg Med Chem Lett
; 18(11): 3359-63, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18456494
17.
Biophysical Interactions of Direct AMPK Activators.
Methods Mol Biol
; 1732: 29-55, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29480467
18.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29466005
19.
Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
Acta Crystallogr F Struct Biol Commun
; 72(Pt 11): 840-845, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27827355
20.
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J Med Chem
; 59(17): 8068-81, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27490827