RESUMEN
INTRODUCTION: Diffuse malignant mesothelioma (MMD) is a rare disease. The diagnosis is difficult and needs an antibody panel. The tumor suppressor gene BRCA1 associated protein 1 (BAP1) is involved in several cancers, including MMD. Loss of BAP1 expression is correlated with BAP1 somatic or constitutional genetic defects. Our work assesses the value of integrating BAP1 in the panel of antibodies used for the diagnosis of MMD. MATERIALS AND METHODS: Immunohistochemical techniques were performed on cytological and histological specimens of MMD and adenocarcinoma pleural metastasis. RESULTS: Of the 26 patients with MMD and the 24 patients with adenocarcinoma pleural metastasis, loss of BAP1 expression was observed in 11 (48%) and one adenocarcinoma (6%) on cytological specimens and in 12 MMD (48%) and in one adenocarcinoma (5%) on biopsy specimens. The concordance between immunocytochemistry and immunohistochemistry was 100%. The specificity of BAP1 was 100% on cytological and biopsy specimen for the diagnosis of malignancy in case of mesothelial proliferation. DISCUSSION AND CONCLUSION: Loss of BAP1 expression is an indicator of MMD in a context of mesothelial proliferation. This immunohistochemistry could be integrated in the panel of immunostaining used for MMD diagnosis, either on histological or cytological samples. Furthermore, loss of BAP1 expression guides the patient to an oncology genetic counseling in order to eliminate a MMD developed as part of a constitutional genetic defect.
Asunto(s)
Biomarcadores de Tumor/análisis , Mesotelioma/química , Proteínas de Neoplasias/análisis , Neoplasias Pleurales/química , Proteínas Supresoras de Tumor/análisis , Ubiquitina Tiolesterasa/análisis , Adenocarcinoma/química , Adenocarcinoma/diagnóstico , Adenocarcinoma/genética , Adenocarcinoma/patología , Anciano , Anciano de 80 o más Años , Biopsia , Diagnóstico Diferencial , Femenino , Regulación Neoplásica de la Expresión Génica , Genes Supresores de Tumor , Asesoramiento Genético , Humanos , Mesotelioma/diagnóstico , Mesotelioma/genética , Mesotelioma/patología , Persona de Mediana Edad , Neoplasias Pleurales/diagnóstico , Neoplasias Pleurales/genética , Neoplasias Pleurales/patología , Sensibilidad y EspecificidadRESUMEN
Idiopathic chylothorax and limb edema was diagnosed in two 2-year-old male whippet siblings. The fact that the 2 related animals developed similar clinical signs at a young age may suggest a congenital or hereditary etiology.
Asunto(s)
Quilotórax/veterinaria , Enfermedades de los Perros/diagnóstico , Linfedema/veterinaria , Animales , Cruzamiento , Quilotórax/congénito , Quilotórax/diagnóstico , Quilotórax/genética , Diagnóstico Diferencial , Enfermedades de los Perros/congénito , Enfermedades de los Perros/genética , Perros , Linfedema/congénito , Linfedema/diagnóstico , Linfedema/genética , MasculinoRESUMEN
Abstract- The literature on food allergy in dogs and cats is reviewed and 33 cases in dogs and 10 cases in cats, seen in Aquitaine, France, are described. Clinical aspects, diagnosis and aetiology are emphasised and compared with published data. Résumé- Cet article fait la synthèse des données bibliographiques concernant l'allergie alimentaire chez le chien et le chat. Puis les auteurs présentent 33 cas de la maladie chez le chien et 10 cas chez le chat, observés en Aquitaine (France). Les aspects cliniques, diagnostiques et étiologiques sont soulignés et comparés aux données de la littérature. Zusammenfassung- In diesem Artikel wird ein Rückblick über die Futtermittel-allergie bie Hund und Katze in der Literatur gegeben. 33 Fälle dieser Erkrankung bei Hunden und 10 bei Katzen in Aquitanien, Frankreich, werden beschrieben. Klinische Aspekte, Diagnostik und Ätiologie werden herausgestellt und mit den Literaturangaben verglichen. Resumen Este artículo presenta una revisión bibliográfica de la alergia alimentaria en el perro y en el gato. A continuación se presentan los datos clinicos de 33 casos de alergia alimentaria en perros y de 10 casos de alergia alimentaria en gatos, diagnosticados en Aquitania, Francia. Se describen los signos clinicos, el diagnóstico y la etiologia y se comparan éstos con los descritos en la bibliografia.