[Complex recto-colic adenomatous and hamartomatous polyposis with hyperplastic gastric polyps in a 13-year-old girl]. / Polypose recto-colique complexe adénomateuse et hamartomateuse avec polypes gastriques hyperplasiques chez une jeune fille de 13 ans.

We report the case of a 13-year-old girl who presented mixed polyposis coli and gastric polyps. The rectal and colonic polyps were of the adenomatous and hamartomatous type (i. e. juvenile and Peutz-Jeghers polyps) without any intermediate features; in the stomach, the polyps were of the hyperplastic type. Microadenomas of the appendix and lymphoid hyperplasia of the ileum were also found. The karyotype was normal and the HLA group was A2 B12. No family history of polyps was discovered. To our knowledge no such case (complex polyposis) has been previously described. The present findings suggest that the usual pathological classification of polyposis may be arbitrary and that various pathological types may represent different aspects of the same spectrum of disease. Absence of "intermediate" polyps rule out the hypothesis of the sequence "hyperplastic polyp-juvenile polyp-adenoma".

[Congenital cystic dilatation of the common bile duct in adults. Apropos of a case diagnosed ultrasonically]. / Dilatation kystique congénitale du cholédoque chez l'adulte. A propos d'un cas diagnostiqué par échographie.

The authors report the observation of a thirty years old woman presenting a choledochal cyst demonstrated by echography. This rare condition is characterized by a segmentary dilatation of the distal portion of the commun bile duct needing surgical treatment. The described case is distinguishable from usual forms by a few own particularities.

[Basic principles of a breast cancer detection program]. / Principes de base d'un programme de dépistage du cancer du sein.

The results of different programmes for screening carried out at present in foreign countries give sufficient proof of the value of screening for cancer of the breast in asymptomatic women of over 50 years of age. There is a significant reduction in mortality between 30 and 70%, according to different studies. Women who were screened had their cancers diagnosed at an earlier stage of the illness than those who were not screened whatever the ages of the women were. These results give a basis for planning screening in France. However, controlled pilot studies should still be carried out to widen screening in a country. These studies should in particular look at technical methods, evaluate the quality of the information that is obtained and the acceptability by women, as well as the training of radiologists and the qualities of the methods used. Finally, each programme should be controlled by the Public Authorities who will be paying for it.

[Utero-ovarian actinomycosis and intrauterine contraceptive devices]. / Actinomycose utéro-ovarienne et dispositif contraceptif intra-utérin.

Up to now a rare affection difficult to diagnose in its abdominal localizations, actinomycosis is becoming of topical interest because of the appearance of a new form of the disease: utero-ovarian infection associated with an intra-uterine contraceptive device (IUD). A recent case, of surgical expression, is reported and used as a basis for an update of epidemiologic and pathogenic data concerning the affection. Diagnosis should be facilitated by regular cytobacteriologic examinations in women with the IUD, and simple preventive measures should limit the number of severe forms sometimes requiring more or less extensive excision.

[Action of granulocyte-colony stimulating factor and cisplatin on two models of human digestive, esophageal and colonic, cancers]. / Action du granulocyte-colony stimulating factor et du cisplatine sur deux modèles de cancers digestifs humains, oesophagien et colique.

A combined therapy using a colony-stimulating factor and a chemotherapeutic agent has been designed, in vitro and in vivo, on digestive tumor cells to assess the effects of these agents administered alone or in combination, on the cells' or the tumor's growth rate. A recombinant human granulocyte colony-stimulating factor (rh G-CSF) and Cisplatin (CDDP) has been administered at various concentrations in vitro on oesophageal (ECYO) or on colonic (COLO 205) cell lines and in vivo on oesophagal tumor transplanted in Nude mice. In vitro, the oesophagal model is sensitive to G-CSF. The administration of G-CSF induces a stimulation of the cell proliferation. The DNA synthesis is stimulated or inhibited by low or high concentrations of G-CSF without any dose-response relationship. CDDP inhibits the DNA synthesis in ECYO cells. The association of the two agents leads to an activation of the DNA synthesis but only for some concentrations. On the contrary, the colonic model treated or not by CDDP is not sensitive to G-CSF. In vivo, G-CSF does not allow any inhibition or activation of oesophagal tumor's growth rate. CDDP alone is also inefficient. When G-CSF is administered before CDDP, there is no effect on the tumors. On the contrary, when G-CSF is administered with or after the chemotherapeutic agent, there is a significant inhibition of the tumor's growth rate.