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1.
Neurochirurgie ; 68(1): 113-116, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33675842

RESUMEN

A multicystic intraventricular tumour of the right ventricular atrium was incidentally diagnosed on follow-up imaging of a 61-year-old man with a history of prostatic adenocarcinoma. Surgical resection of the lesion was performed after a one-year radio-clinical follow-up due to progressive expansion of the lesion size and a rising prostate specific antigen blood-level. Morphological features with papillary pattern on pathological examination were compatible with malignant adenocarcinoma or choroid plexus carcinoma. The immunoprofile was conclusive for an exceptional choroid plexus metastasis (CPM) of a prostatic adenocarcinoma. To our knowledge, this is the first report of a proven prostatic origin of a CPM.


Asunto(s)
Adenocarcinoma , Carcinoma , Neoplasias del Plexo Coroideo , Neoplasias de la Próstata , Adenocarcinoma/patología , Plexo Coroideo , Neoplasias del Plexo Coroideo/diagnóstico , Neoplasias del Plexo Coroideo/secundario , Neoplasias del Plexo Coroideo/cirugía , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Neoplasias de la Próstata/patología
2.
Methods Enzymol ; 587: 55-70, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28253976

RESUMEN

Macroautophagy (usually referred to as autophagy) is the most important degradation system in mammalian cells. It is responsible for the elimination of protein aggregates, organelles, and other cellular content. During autophagy, these materials (i.e., cargo) must be engulfed by a double-membrane structure called an autophagosome, which delivers the cargo to the lysosome to complete its degradation. Autophagy is a very dynamic pathway called autophagic flux. The process involves all the steps that are implicated in cargo degradation from autophagosome formation. There are several techniques to monitor autophagic flux. Among them, the method most used experimentally to assess autophagy is the detection of LC3 protein processing and p62 degradation by Western blotting. In this chapter, we provide a detailed and straightforward protocol for this purpose in cultured mammalian cells, including a brief set of notes concerning problems associated with the Western-blotting detection of LC3 and p62.


Asunto(s)
Autofagia/fisiología , Proteínas Asociadas a Microtúbulos/metabolismo , Biología Molecular/métodos , Animales , Western Blotting , Células Cultivadas , Electroforesis/métodos , Fibroblastos/metabolismo , Ratones , Proteínas Asociadas a Microtúbulos/análisis , Proteína Sequestosoma-1/metabolismo
3.
Mol Neurobiol ; 54(8): 6287-6303, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-27714635

RESUMEN

Mitochondria-associated membranes (MAMs) are structures that regulate physiological functions between endoplasmic reticulum (ER) and mitochondria in order to maintain calcium signaling and mitochondrial biogenesis. Several proteins located in MAMs, including those encoded by PARK genes and some of neurodegeneration-related proteins (huntingtin, presenilin, etc.), ensure this regulation. In this regard, MAM alteration is associated with neurodegenerative diseases such as Parkinson's (PD), Alzheimer's (AD), and Huntington's diseases (HD) and contributes to the appearance of the pathogenesis features, i.e., autophagy dysregulation, mitochondrial dysfunction, oxidative stress, and lately, neuronal death. Moreover,, ER stress and/or damaged mitochondria can be the cause of these disruptions. Therefore, ER-mitochondria contact structure and function are crucial to multiple cellular processes. This review is focused on the molecular interaction between ER and mitochondria indispensable to MAM formation and on MAM alteration-induced etiology of neurodegenerative diseases.


Asunto(s)
Muerte Celular/fisiología , Retículo Endoplásmico/metabolismo , Membranas Mitocondriales/metabolismo , Estrés Oxidativo/fisiología , Enfermedad de Parkinson/metabolismo , Animales , Humanos , Mitocondrias/metabolismo , Biogénesis de Organelos
4.
Curr Med Chem ; 23(21): 2275-85, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27237817

RESUMEN

Pompe disease or glycogen storage disease type II (OMIM: 232300) is a lysosomal storage disorder resulting from a partial or total lack of acid alphaglucosidase, which may produce muscle weakness, gait abnormalities, or even death by respiratory failure. In the last decade, autophagy has been proposed as a mechanism involved in the severity of symptoms related to this disorder and as a potential therapeutic target to alleviate disease progression. This review summarizes the relationship between autophagy and Pompe disease, including what information has been recently discovered and what remains unclear.


Asunto(s)
Autofagia , Enfermedad del Almacenamiento de Glucógeno Tipo II/patología , Animales , Modelos Animales de Enfermedad , Terapia de Reemplazo Enzimático , Enfermedad del Almacenamiento de Glucógeno Tipo II/metabolismo , Enfermedad del Almacenamiento de Glucógeno Tipo II/terapia , Humanos , Proteínas Asociadas a Microtúbulos/metabolismo , Mitocondrias/metabolismo , Músculo Esquelético/metabolismo , alfa-Glucosidasas/genética , alfa-Glucosidasas/metabolismo
5.
Neurochirurgie ; 61(1): 46-9, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25595594

RESUMEN

We report on a young woman with a left temporal diffuse low-grade glioma treated initially by a subtotal resection. A focal anaplastic area appeared 5years later and was treated by radiosurgery. A long-time stabilization was therefore obtained and lasted even after pregnancy, which is a known factor of faster tumour progression. This report shows that radiosurgery could be an option in the multimodal treatment of a selected group of patients with focal malignant transformation of diffuse low-grade glioma. It could permit long-term stabilization of the tumour without any other adjuvant treatment and without compromising the quality of life.


Asunto(s)
Neoplasias Encefálicas/cirugía , Carcinoma/cirugía , Oligodendroglioma/cirugía , Radiocirugia/métodos , Adolescente , Anticonvulsivantes , Femenino , Humanos , Imagen por Resonancia Magnética , Embarazo , Convulsiones/tratamiento farmacológico , Convulsiones/etiología , Sobrevivientes , Resultado del Tratamiento
6.
Neurochirurgie ; 42(4-5): 209-15, 1996.
Artículo en Francés | MEDLINE | ID: mdl-9084748

RESUMEN

From September 1976 to November 1991 a series of 34 patients with peripheral iatrogenal facial paralysis after removal of cerebellopontine angle tumors or parotid-gland surgery were treated by hypoglossal-facial anastomosis (hypoglossal-facial/hypoglossal-hypoglossal in 38.24% of cases). Patients were divided into two groups: Group A with early anastomosis and Group B with delayed anastomosis. In the first group, 57.14% of the cases presented "excessive reinnervation"; and in the second group, 95.0% of cases presented "good" or "excellent" results. In this paper we analyze and discuss our results and review the literature.


Asunto(s)
Nervio Facial/cirugía , Parálisis Facial/cirugía , Nervio Hipogloso/cirugía , Adulto , Anciano , Anastomosis Quirúrgica , Estudios de Evaluación como Asunto , Parálisis Facial/rehabilitación , Femenino , Estudios de Seguimiento , Humanos , Enfermedad Iatrogénica , Masculino , Persona de Mediana Edad , Unión Neuromuscular/fisiopatología , Cuidados Paliativos , Factores de Tiempo
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