Búsqueda | Biblioteca Virtual en Salud Fronteriza

1.

Molecular basis of opioid receptor signaling.

Che, Tao; Roth, Bryan L.

Cell ; 186(24): 5203-5219, 2023 11 22.

Artículo en Inglés | MEDLINE | ID: mdl-37995655

2.

SnapShot: Psychedelics and serotonin receptor signaling.

Gumpper, Ryan H; Roth, Bryan L.

Cell ; 186(1): 232-232.e1, 2023 01 05.

Artículo en Inglés | MEDLINE | ID: mdl-36608655

3.

Structures of the entire human opioid receptor family.

Wang, Yue; Zhuang, Youwen; DiBerto, Jeffrey F; Zhou, X Edward; Schmitz, Gavin P; Yuan, Qingning; Jain, Manish K; Liu, Weiyi; Melcher, Karsten; Jiang, Yi; Roth, Bryan L; Xu, H Eric.

Cell ; 186(2): 413-427.e17, 2023 01 19.

Artículo en Inglés | MEDLINE | ID: mdl-36638794

4.

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.

Singh, Isha; Seth, Anubha; Billesbølle, Christian B; Braz, Joao; Rodriguiz, Ramona M; Roy, Kasturi; Bekele, Bethlehem; Craik, Veronica; Huang, Xi-Ping; Boytsov, Danila; Pogorelov, Vladimir M; Lak, Parnian; O'Donnell, Henry; Sandtner, Walter; Irwin, John J; Roth, Bryan L; Basbaum, Allan I; Wetsel, William C; Manglik, Aashish; Shoichet, Brian K; Rudnick, Gary.

Cell ; 186(10): 2160-2175.e17, 2023 05 11.

Artículo en Inglés | MEDLINE | ID: mdl-37137306

5.

Structural Insights Accelerate the Discovery of Opioid Alternatives.

Che, Tao; Roth, Bryan L.

Annu Rev Biochem ; 90: 739-761, 2021 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-33756098

6.

Structural insights into the human D1 and D2 dopamine receptor signaling complexes.

Zhuang, Youwen; Xu, Peiyu; Mao, Chunyou; Wang, Lei; Krumm, Brian; Zhou, X Edward; Huang, Sijie; Liu, Heng; Cheng, Xi; Huang, Xi-Ping; Shen, Dan-Dan; Xu, Tinghai; Liu, Yong-Feng; Wang, Yue; Guo, Jia; Jiang, Yi; Jiang, Hualiang; Melcher, Karsten; Roth, Bryan L; Zhang, Yan; Zhang, Cheng; Xu, H Eric.

Cell ; 184(4): 931-942.e18, 2021 02 18.

Artículo en Inglés | MEDLINE | ID: mdl-33571431

7.

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT_2A Serotonin Receptor.

Kim, Kuglae; Che, Tao; Panova, Ouliana; DiBerto, Jeffrey F; Lyu, Jiankun; Krumm, Brian E; Wacker, Daniel; Robertson, Michael J; Seven, Alpay B; Nichols, David E; Shoichet, Brian K; Skiniotis, Georgios; Roth, Bryan L.

Cell ; 182(6): 1574-1588.e19, 2020 09 17.

Artículo en Inglés | MEDLINE | ID: mdl-32946782

8.

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.

English, Justin G; Olsen, Reid H J; Lansu, Katherine; Patel, Michael; White, Karoline; Cockrell, Adam S; Singh, Darshan; Strachan, Ryan T; Wacker, Daniel; Roth, Bryan L.

Cell ; 178(3): 748-761.e17, 2019 07 25.

Artículo en Inglés | MEDLINE | ID: mdl-31280962

9.

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.

Foster, Simon R; Hauser, Alexander S; Vedel, Line; Strachan, Ryan T; Huang, Xi-Ping; Gavin, Ariana C; Shah, Sushrut D; Nayak, Ajay P; Haugaard-Kedström, Linda M; Penn, Raymond B; Roth, Bryan L; Bräuner-Osborne, Hans; Gloriam, David E.

Cell ; 179(4): 895-908.e21, 2019 10 31.

Artículo en Inglés | MEDLINE | ID: mdl-31675498

10.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che, Tao; Majumdar, Susruta; Zaidi, Saheem A; Ondachi, Pauline; McCorvy, John D; Wang, Sheng; Mosier, Philip D; Uprety, Rajendra; Vardy, Eyal; Krumm, Brian E; Han, Gye Won; Lee, Ming-Yue; Pardon, Els; Steyaert, Jan; Huang, Xi-Ping; Strachan, Ryan T; Tribo, Alexandra R; Pasternak, Gavril W; Carroll, F Ivy; Stevens, Raymond C; Cherezov, Vadim; Katritch, Vsevolod; Wacker, Daniel; Roth, Bryan L.

Cell ; 172(1-2): 55-67.e15, 2018 01 11.

Artículo en Inglés | MEDLINE | ID: mdl-29307491

11.

5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng, Yao; McCorvy, John D; Harpsøe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F; Huang, Xi-Ping; Wu, Yiran; Shen, Ling; Bjørn-Yoshimoto, Walden E; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A; Hanson, Michael A; Zhao, Suwen; Gloriam, David E; Roth, Bryan L; Stevens, Raymond C; Liu, Zhi-Jie.

Cell ; 172(4): 719-730.e14, 2018 02 08.

Artículo en Inglés | MEDLINE | ID: mdl-29398112

12.

How Ligands Illuminate GPCR Molecular Pharmacology.

Wacker, Daniel; Stevens, Raymond C; Roth, Bryan L.

Cell ; 170(3): 414-427, 2017 Jul 27.

Artículo en Inglés | MEDLINE | ID: mdl-28753422

13.

Crystal Structure of an LSD-Bound Human Serotonin Receptor.

Wacker, Daniel; Wang, Sheng; McCorvy, John D; Betz, Robin M; Venkatakrishnan, A J; Levit, Anat; Lansu, Katherine; Schools, Zachary L; Che, Tao; Nichols, David E; Shoichet, Brian K; Dror, Ron O; Roth, Bryan L.

Cell ; 168(3): 377-389.e12, 2017 01 26.

Artículo en Inglés | MEDLINE | ID: mdl-28129538

14.

Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP.

Kapolka, Nicholas J; Roth, Bryan L.

Mol Cell ; 83(14): 2392-2394, 2023 07 20.

Artículo en Inglés | MEDLINE | ID: mdl-37478823

15.

Alternative splicing of latrophilin-3 controls synapse formation.

Wang, Shuai; DeLeon, Chelsea; Sun, Wenfei; Quake, Stephen R; Roth, Bryan L; Südhof, Thomas C.

Nature ; 626(7997): 128-135, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38233523

16.

Bitter taste receptor activation by cholesterol and an intracellular tastant.

Kim, Yoojoong; Gumpper, Ryan H; Liu, Yongfeng; Kocak, D Dewran; Xiong, Yan; Cao, Can; Deng, Zhijie; Krumm, Brian E; Jain, Manish K; Zhang, Shicheng; Jin, Jian; Roth, Bryan L.

Nature ; 628(8008): 664-671, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38600377

17.

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.

English, Justin G; Olsen, Reid H J; Lansu, Katherine; Patel, Michael; White, Karoline; Cockrell, Adam S; Singh, Darshan; Strachan, Ryan T; Wacker, Daniel; Roth, Bryan L.

Cell ; 178(4): 1030, 2019 Aug 08.

Artículo en Inglés | MEDLINE | ID: mdl-31398329

18.

Structure-based design of bitopic ligands for the µ-opioid receptor.

Faouzi, Abdelfattah; Wang, Haoqing; Zaidi, Saheem A; DiBerto, Jeffrey F; Che, Tao; Qu, Qianhui; Robertson, Michael J; Madasu, Manish K; El Daibani, Amal; Varga, Balazs R; Zhang, Tiffany; Ruiz, Claudia; Liu, Shan; Xu, Jin; Appourchaux, Kevin; Slocum, Samuel T; Eans, Shainnel O; Cameron, Michael D; Al-Hasani, Ream; Pan, Ying Xian; Roth, Bryan L; McLaughlin, Jay P; Skiniotis, Georgios; Katritch, Vsevolod; Kobilka, Brian K; Majumdar, Susruta.

Nature ; 613(7945): 767-774, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36450356

19.

Structures of the human dopamine D3 receptor-G_i complexes.

Xu, Peiyu; Huang, Sijie; Mao, Chunyou; Krumm, Brian E; Zhou, X Edward; Tan, Yangxia; Huang, Xi-Ping; Liu, Yongfeng; Shen, Dan-Dan; Jiang, Yi; Yu, Xuekui; Jiang, Hualiang; Melcher, Karsten; Roth, Bryan L; Cheng, Xi; Zhang, Yan; Xu, H Eric.

Mol Cell ; 81(6): 1147-1159.e4, 2021 03 18.

Artículo en Inglés | MEDLINE | ID: mdl-33548201

20.

Conformational ensembles in GPCR activation.

Vardy, Eyal; Roth, Bryan L.

Cell ; 152(3): 385-6, 2013 Jan 31.

Artículo en Inglés | MEDLINE | ID: mdl-23374334

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Molecular basis of opioid receptor signaling.

SnapShot: Psychedelics and serotonin receptor signaling.

Structures of the entire human opioid receptor family.

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.

Structural Insights Accelerate the Discovery of Opioid Alternatives.

Structural insights into the human D1 and D2 dopamine receptor signaling complexes.

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT_2A Serotonin Receptor.

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

How Ligands Illuminate GPCR Molecular Pharmacology.

Crystal Structure of an LSD-Bound Human Serotonin Receptor.

Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP.

Alternative splicing of latrophilin-3 controls synapse formation.

Bitter taste receptor activation by cholesterol and an intracellular tastant.

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.

Structure-based design of bitopic ligands for the µ-opioid receptor.

Structures of the human dopamine D3 receptor-G_i complexes.

Conformational ensembles in GPCR activation.