RESUMEN
A 52-year-old woman with recurrent high-grade endometrial stromal sarcoma presented with left hypochondralgia. She had undergone total hysterectomy and bilateral salpingo-oophorectomy for the disease over the past six months, and preferred not to receive additional treatment. The following regimen of chemotherapy was given: each course consisted of ifosfamide (1,000 mg/m²) on days 1-5, adriamycin (60 mg/m²) on day 1, and cisplatin (15 mg/m²) on days 1-5. After 4 courses of the chemotherapy, the intraabdominal mass and multiple pulmonary nodules were reduced 45. 1% from the beginning. This case suggests that IAP might be effective chemotherapy for patients with high-grade endometrial stromal sarcoma.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Cisplatino/uso terapéutico , Doxorrubicina/uso terapéutico , Neoplasias Endometriales/tratamiento farmacológico , Ifosfamida/uso terapéutico , Sarcoma Estromático Endometrial/tratamiento farmacológico , Neoplasias Abdominales/diagnóstico por imagen , Neoplasias Abdominales/tratamiento farmacológico , Neoplasias Abdominales/secundario , Cisplatino/administración & dosificación , Doxorrubicina/administración & dosificación , Neoplasias Endometriales/diagnóstico por imagen , Neoplasias Endometriales/patología , Neoplasias Endometriales/cirugía , Femenino , Humanos , Ifosfamida/administración & dosificación , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/secundario , Persona de Mediana Edad , Recurrencia , Sarcoma Estromático Endometrial/diagnóstico por imagen , Sarcoma Estromático Endometrial/patología , Sarcoma Estromático Endometrial/cirugía , Tomografía Computarizada por Rayos XRESUMEN
Fibroblast growth factor (FGF) induces the notochord and mesenchyme in ascidian embryos, via extracellular signal-regulated kinase (ERK) that belongs to the mitogen-activated protein kinase (MAPK) family. A cDNA microarray analysis was carried out to identify genes affected by an inhibitor of MAPK/ERK kinase (MEK), U0126, in embryos of the ascidian Ciona intestinalis. Data obtained from the microarray and in situ hybridization suggest that the majority of genes are downregulated by U0126 treatment. Genes that were downregulated in U0126-treated embryos included Ci-Bra and Ci-Twist-like1 that are master regulatory genes of notochord and mesenchyme differentiation, respectively. The plasminogen mRNA was downregulated by U0126 in presumptive endoderm cells. This suggests that a MEK-mediated extracellular signal is necessary for gene expression in tissues whose specification does not depend on cell-to-cell interaction. Among 85 cDNA clusters that were not affected by U0126, 30 showed mitochondria-like mRNA localization in the nerve cord/muscle lineage blastomeres in the equatorial region. The expression level and asymmetric distribution of these mRNA were independent of MEK signaling.