Búsqueda | Biblioteca Virtual en Salud Fronteriza

1.

PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.

Dhingra, Yukti; Suresh, Shravanti K; Juneja, Puneet; Sashital, Dipali G.

Mol Cell ; 82(22): 4353-4367.e6, 2022 11 17.

Artículo en Inglés | MEDLINE | ID: mdl-36272411

2.

Creating memories: molecular mechanisms of CRISPR adaptation.

Lee, Hayun; Sashital, Dipali G.

Trends Biochem Sci ; 47(6): 464-476, 2022 06.

Artículo en Inglés | MEDLINE | ID: mdl-35236570

3.

CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes.

Schelling, Michael A; Nguyen, Giang T; Sashital, Dipali G.

PLoS Biol ; 21(4): e3002065, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-37058530

4.

Cas4-Dependent Prespacer Processing Ensures High-Fidelity Programming of CRISPR Arrays.

Lee, Hayun; Zhou, Yi; Taylor, David W; Sashital, Dipali G.

Mol Cell ; 70(1): 48-59.e5, 2018 04 05.

Artículo en Inglés | MEDLINE | ID: mdl-29602742

5.

CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes.

Adler, Benjamin A; Trinidad, Marena I; Bellieny-Rabelo, Daniel; Zhang, Elaine; Karp, Hannah M; Skopintsev, Petr; Thornton, Brittney W; Weissman, Rachel F; Yoon, Peter H; Chen, LinXing; Hessler, Tomas; Eggers, Amy R; Colognori, David; Boger, Ron; Doherty, Erin E; Tsuchida, Connor A; Tran, Ryan V; Hofman, Laura; Shi, Honglue; Wasko, Kevin M; Zhou, Zehan; Xia, Chenglong; Al-Shimary, Muntathar J; Patel, Jaymin R; Thomas, Vienna C J X; Pattali, Rithu; Kan, Matthew J; Vardapetyan, Anna; Yang, Alana; Lahiri, Arushi; Maxwell, Micaela F; Murdock, Andrew G; Ramit, Glenn C; Henderson, Hope R; Calvert, Roland W; Bamert, Rebecca S; Knott, Gavin J; Lapinaite, Audrone; Pausch, Patrick; Cofsky, Joshua C; Sontheimer, Erik J; Wiedenheft, Blake; Fineran, Peter C; Brouns, Stan J J; Sashital, Dipali G; Thomas, Brian C; Brown, Christopher T; Goltsman, Daniela S A; Barrangou, Rodolphe; Siksnys, Virginius.

Nucleic Acids Res ; 52(D1): D590-D596, 2024 Jan 05.

Artículo en Inglés | MEDLINE | ID: mdl-37889041

6.

Prokaryotic Argonaute Uses an All-in-One Mechanism to Provide Host Defense.

Sashital, Dipali G.

Mol Cell ; 65(6): 957-958, 2017 Mar 16.

Artículo en Inglés | MEDLINE | ID: mdl-28306508

7.

The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit.

Murugan, Karthik; Babu, Kesavan; Sundaresan, Ramya; Rajan, Rakhi; Sashital, Dipali G.

Mol Cell ; 68(1): 15-25, 2017 Oct 05.

Artículo en Inglés | MEDLINE | ID: mdl-28985502

8.

Cas4/1 dual nuclease activities enable prespacer maturation and directional integration in a type I-G CRISPR-Cas system.

Dhingra, Yukti; Sashital, Dipali G.

J Biol Chem ; 299(9): 105178, 2023 09.

Artículo en Inglés | MEDLINE | ID: mdl-37607619

9.

Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity.

Xue, Chaoyou; Whitis, Natalie R; Sashital, Dipali G.

Mol Cell ; 64(4): 826-834, 2016 11 17.

Artículo en Inglés | MEDLINE | ID: mdl-27871367

10.

Systematic in vitro specificity profiling reveals nicking defects in natural and engineered CRISPR-Cas9 variants.

Murugan, Karthik; Suresh, Shravanti K; Seetharam, Arun S; Severin, Andrew J; Sashital, Dipali G.

Nucleic Acids Res ; 49(7): 4037-4053, 2021 04 19.

Artículo en Inglés | MEDLINE | ID: mdl-33744974

11.

CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects.

Murugan, Karthik; Seetharam, Arun S; Severin, Andrew J; Sashital, Dipali G.

J Biol Chem ; 295(17): 5538-5553, 2020 04 24.

Artículo en Inglés | MEDLINE | ID: mdl-32161115

12.

Mechanism of foreign DNA selection in a bacterial adaptive immune system.

Sashital, Dipali G; Wiedenheft, Blake; Doudna, Jennifer A.

Mol Cell ; 46(5): 606-15, 2012 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-22521690

13.

CRISPR interference and priming varies with individual spacer sequences.

Xue, Chaoyou; Seetharam, Arun S; Musharova, Olga; Severinov, Konstantin; Brouns, Stan J J; Severin, Andrew J; Sashital, Dipali G.

Nucleic Acids Res ; 43(22): 10831-47, 2015 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-26586800

14.

Structure of the yeast U2/U6 snRNA complex.

Burke, Jordan E; Sashital, Dipali G; Zuo, Xiaobing; Wang, Yun-Xing; Butcher, Samuel E.

RNA ; 18(4): 673-83, 2012 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-22328579

15.

CRISPR-Cas12a exhibits metal-dependent specificity switching.

Nguyen, Giang T; Schelling, Michael A; Buscher, Kathryn A; Sritharan, Aneisha; Sashital, Dipali G.

bioRxiv ; 2024 Jan 17.

Artículo en Inglés | MEDLINE | ID: mdl-38076861

16.

A tool for more specific DNA integration.

Dhingra, Yukti; Sashital, Dipali G.

Science ; 382(6672): 768-769, 2023 11 17.

Artículo en Inglés | MEDLINE | ID: mdl-37972178

17.

Cas4/1 dual nuclease activities enable prespacer maturation and directional integration in a type I-G CRISPR-Cas system.

Dhingra, Yukti; Sashital, Dipali G.

bioRxiv ; 2023 Jun 05.

Artículo en Inglés | MEDLINE | ID: mdl-37333257

18.

Miniature CRISPR-Cas12 endonucleases - Programmed DNA targeting in a smaller package.

Nguyen, Giang T; Dhingra, Yukti; Sashital, Dipali G.

Curr Opin Struct Biol ; 77: 102466, 2022 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-36170778

19.

An adaptable defense.

Schelling, Michael A; Sashital, Dipali G.

Elife ; 92020 03 30.

Artículo en Inglés | MEDLINE | ID: mdl-32223888

20.

U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction.

Sashital, Dipali G; Cornilescu, Gabriel; McManus, C Joel; Brow, David A; Butcher, Samuel E.

Nat Struct Mol Biol ; 11(12): 1237-42, 2004 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-15543154

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PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.

Creating memories: molecular mechanisms of CRISPR adaptation.

CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes.

Cas4-Dependent Prespacer Processing Ensures High-Fidelity Programming of CRISPR Arrays.

CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes.

Prokaryotic Argonaute Uses an All-in-One Mechanism to Provide Host Defense.

The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit.

Cas4/1 dual nuclease activities enable prespacer maturation and directional integration in a type I-G CRISPR-Cas system.

Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity.

Systematic in vitro specificity profiling reveals nicking defects in natural and engineered CRISPR-Cas9 variants.

CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects.

Mechanism of foreign DNA selection in a bacterial adaptive immune system.

CRISPR interference and priming varies with individual spacer sequences.

Structure of the yeast U2/U6 snRNA complex.

CRISPR-Cas12a exhibits metal-dependent specificity switching.

A tool for more specific DNA integration.

Cas4/1 dual nuclease activities enable prespacer maturation and directional integration in a type I-G CRISPR-Cas system.

Miniature CRISPR-Cas12 endonucleases - Programmed DNA targeting in a smaller package.

An adaptable defense.

U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction.