RESUMEN
OBJECTIVE: Past studies have reported associations between pesticide exposure and the risk of systemic lupus erythematosus (SLE). Residential pesticide exposure has been less well studied than agricultural exposure. The purpose of this study was to assess SLE risk associated with residential pesticide exposure in an urban population of predominantly African-American women. METHODS: Adult women with SLE were identified from six hospital databases and community screening in three neighborhoods in Boston, Massachusetts, USA. Controls were adult women volunteers from the same neighborhoods who were screened for the absence of connective tissue disease and anti-nuclear antibodies. Subjects were considered exposed to pesticides if they had ever had an exterminator for an ant, cockroach, or termite problem prior to SLE diagnosis or corresponding reference age in controls. Risks associated with pesticide exposure were analyzed using multivariable logistic regression models, adjusted for sociodemographic factors. RESULTS: We identified 93 SLE subjects and 170 controls with similar baseline characteristics. Eighty-three per cent were African-American. Pesticide exposure was associated with SLE, after controlling for potential confounders (odds ratio 2.24, 95% confidence interval 1.28-3.93). CONCLUSION: Residential exposure to pesticides in an urban population of predominantly African-American women was associated with increased SLE risk. Additional studies are needed to corroborate these findings.
Asunto(s)
Negro o Afroamericano/estadística & datos numéricos , Lupus Eritematoso Sistémico/inducido químicamente , Lupus Eritematoso Sistémico/epidemiología , Plaguicidas/efectos adversos , Adulto , Anticuerpos Antinucleares , Estudios de Casos y Controles , Exposición a Riesgos Ambientales/efectos adversos , Contaminantes Ambientales/efectos adversos , Femenino , Humanos , Modelos Logísticos , Massachusetts/epidemiología , Persona de Mediana Edad , Análisis Multivariante , Factores de Riesgo , Población UrbanaAsunto(s)
Pediatría , Preescolar , Países en Desarrollo , Empleos en Salud/educación , Humanos , NigeriaAsunto(s)
Linfoma de Burkitt/epidemiología , Neoplasias/epidemiología , Factores de Edad , Linfoma de Burkitt/diagnóstico , Linfoma de Burkitt/terapia , Niño , Preescolar , Femenino , Humanos , Lactante , Leucemia/epidemiología , Masculino , Sistema Mononuclear Fagocítico , Neoplasias/mortalidad , Nigeria , Factores SexualesAsunto(s)
Servicios de Salud para Estudiantes , Anemia/sangre , Antropometría , Niño , Caries Dental/diagnóstico , Femenino , Pruebas Auditivas , Hematócrito , Humanos , Inmunización , Masculino , Ciudad de Nueva York , Examen Físico , Instituciones Académicas , Prueba de Tuberculina , Pruebas de VisiónRESUMEN
All childhood accidents treated at the University College Hospital, Ibadan, Nigeria, during a 4-year period are analysed. The pattern of childhood injuries in the part of Nigeria served by this hospital does not differ significantly from the pattern reported in studies from other parts of the world. The chain of events leading to an accident appears in large measure to be directly influenced by the mode of life in the community. This in turn is related to the prevailing level of technological development.There is an obvious need for more exhaustive studies of childhood accidents in developing countries. However, these countries need not wait for this information to become available before initiating accident-prevention programmes.