1.
Bioorg Med Chem Lett
; 20(15): 4472-4, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20615702
RESUMEN
5-Alkyl and aryl-pyrazole-acids have been identified as a new class of selective, small-molecule, agonists of the human orphan G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.
Asunto(s)
Pirazoles/química , Receptores Acoplados a Proteínas G/agonistas , Animales , Ácidos Grasos/metabolismo , Humanos , Ratones , Niacina/química , Pirazoles/síntesis química , Pirazoles/farmacocinética , Receptores Acoplados a Proteínas G/metabolismo , Receptores Nicotínicos/metabolismo
2.
Bioorg Med Chem Lett
; 19(8): 2121-4, 2009 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19307116
RESUMEN
5-Alkyl and aryl-pyrazole-tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.