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1.
Angew Chem Int Ed Engl ; 57(18): 5006-5010, 2018 04 23.
Artículo en Inglés | MEDLINE | ID: mdl-29488673

RESUMEN

A cyclic-voltammetry-based screening method for Cp2 TiX-catalyzed reactions is introduced. Our mechanism-based approach enables the study of the influence of various additives on the electrochemically generated active catalyst Cp2 TiX, which is in equilibrium with catalytically inactive [Cp2 TiX2 ]- . Thioureas and ureas are most efficient in the generation of Cp2 TiX in THF. Knowing the precise position of the equilibrium between Cp2 TiX and [Cp2 TiX2 ]- allowed us to identify reaction conditions for the bulk electrolysis of Cp2 TiX2 complexes and for Cp2 TiX-catayzed radical arylations without having to carry out the reactions. Our time- and resource-efficient approach is of general interest for the design of catalytic reactions that proceed in single-electron steps.

2.
J Am Chem Soc ; 139(23): 7761-7767, 2017 06 14.
Artículo en Inglés | MEDLINE | ID: mdl-28443329

RESUMEN

Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization source. However, current SABRE faces a number of stumbling blocks for translation to biochemical and clinical settings. Difficulties include inefficient polarization in water, relatively short-lived 1H-polarization, and relatively limited substrate scope. Here we use a water-soluble polarization transfer catalyst to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei). This strategy works in pure H2O or D2O solutions, on substrates that could not be hyperpolarized in traditional 1H-SABRE experiments, and we record 15N T1 relaxation times of up to 2 min.


Asunto(s)
Hidrógeno/química , Isótopos de Nitrógeno/química , Espectroscopía de Resonancia Magnética , Estructura Molecular , Agua/química
3.
Chemphyschem ; 18(18): 2426-2429, 2017 Sep 20.
Artículo en Inglés | MEDLINE | ID: mdl-28682000

RESUMEN

Studies of water-based systems are of fundamental interest for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) as water is the most abundant and important medium for global living. Hence, increasing the polarization of water and dissolved compounds is particularly attractive for biomedical applications such as investigations of intermolecular interactions and metabolite structures as well as for imaging purposes. In this work, we show a new approach based on para enriched hydrogen (p-H2 ) that enables the hyperpolarization of bulk water if a suitable catalytic system is employed. The results indicate that the polarization is transferred by a new exchange mechanism.

4.
Chemistry ; 22(27): 9277-82, 2016 Jun 27.
Artículo en Inglés | MEDLINE | ID: mdl-27258850

RESUMEN

NMR signal amplification by reversible exchange (SABRE) has been observed for pyridine, methyl nicotinate, N-methylnicotinamide, and nicotinamide in D2 O with the new catalyst [Ir(Cl)(IDEG)(COD)] (IDEG=1,3-bis(3,4,5-tris(diethyleneglycol)benzyl)imidazole-2-ylidene). During the activation and hyperpolarization steps, exclusively D2 O was used, resulting in the first fully biocompatible SABRE system. Hyperpolarized (1) H substrate signals were observed at 42.5 MHz upon pressurizing the solution with parahydrogen at close to the Earth's magnetic field, at concentrations yielding barely detectable thermal signals. Moreover, 42-, 26-, 22-, and 9-fold enhancements were observed for nicotinamide, pyridine, methyl nicotinate, and N-methylnicotinamide, respectively, in conventional 300 MHz studies. This research opens up new opportunities in a field in which SABRE has hitherto primarily been conducted in CD3 OD. This system uses simple hardware, leaves the substrate unaltered, and shows that SABRE is potentially suitable for clinical purposes.


Asunto(s)
Complejos de Coordinación/química , Óxido de Deuterio/química , Iridio/química , Niacinamida/análogos & derivados , Materiales Biocompatibles/síntesis química , Materiales Biocompatibles/química , Catálisis , Complejos de Coordinación/síntesis química , Cristalografía por Rayos X , Espectroscopía de Resonancia Magnética , Conformación Molecular , Niacinamida/química , Agua/química
5.
Org Biomol Chem ; 12(13): 2062-70, 2014 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-24448762

RESUMEN

The limited availability of catalytic reaction components may represent a major hurdle for the practical application of many catalytic procedures in organic synthesis. In this work, we demonstrate that the mixture of isomeric iron complexes [Fe(OTf)2(mix-BPBP)] (mix-1), composed of Λ-α-[Fe(OTf)2(S,S-BPBP)] (S,S-1), Δ-α-[Fe(OTf)2(R,R-BPBP)] (R,R-1) and Δ/Λ-ß-[Fe(OTf)2(R,S-BPBP)] (R,S-1), is a practical catalyst for the preparative oxidation of various aliphatic compounds including model hydrocarbons and optically pure natural products using hydrogen peroxide as an oxidant. Among the species present in mix-1, S,S-1 and R,R-1 are catalytically active, act independently and represent ca. 75% of mix-1. The remaining 25% of mix-1 is represented by mesomeric R,S-1 which nominally plays a spectator role in both C-H and C[double bond, length as m-dash]C bond oxidation reactions. Overall, this mixture of iron complexes displays the same catalytic profile as its enantiopure components that have been previously used separately in sp(3) C-H oxidations. In contrast to them, mix-1 is readily available on a multi-gram scale via two high yielding steps from crude dl/meso-2,2'-bipyrrolidine. Next to its use in C-H oxidation, mix-1 is active in chemospecific epoxidation reactions, which has allowed us to develop a practical catalytic protocol for the synthesis of epoxides.


Asunto(s)
Productos Biológicos/química , Compuestos Epoxi/síntesis química , Compuestos Ferrosos/química , Hidrocarburos/química , Peróxido de Hidrógeno/química , Piridinas/química , Pirrolidinas/química , Catálisis , Compuestos Epoxi/química , Estructura Molecular , Oxidación-Reducción
6.
Chemistry ; 19(44): 15012-8, 2013 Oct 25.
Artículo en Inglés | MEDLINE | ID: mdl-24105732

RESUMEN

A one-pot method has been developed for the oxidative cleavage of internal alkenes into aldehydes by using 0.5 mol% of the nonheme iron complex [Fe(OTf)2(mix-bpbp)] (bpbp=N,N'-bis(2-picolyl)-2,2'-bipyrrolidine) as catalyst and 1.5 equivalents of hydrogen peroxide and 1 equivalent of sodium periodate as oxidants. A mixture of diastereomers of the chiral bpbp ligand can be used, thereby omitting the need for resolution of its optically active components. The cleavage reaction can be performed in one pot within 20 h and under ambient conditions. Addition of water after the epoxidation, acidification and subsequent pH neutralization are crucial to perform the epoxidation, hydrolysis, and subsequent diol cleavage in one pot. High aldehyde yields can be obtained for the cleavage of internal aliphatic double bonds with cis and trans configuration (86-98%) and unsaturated fatty acids and esters (69-96%). Good aldehyde yields are obtained in reactions of trisubstituted and terminal alkenes (62-63%). The products can be easily isolated by a simple extraction step with an organic solvent. The presented protocol involves a lower catalyst loading than conventional methods based on Ru or Os. Also, hydrogen peroxide can be used as the oxidant in this case, which is often disproportionated by second- and third-row metals. By using only mild oxidants, overoxidation of the aldehyde to the carboxylic acid is prevented.


Asunto(s)
Aldehídos/química , Aldehídos/síntesis química , Ácidos Grasos Insaturados/química , Peróxido de Hidrógeno/química , Hierro/química , Ácido Peryódico/química , Catálisis , Estructura Molecular , Oxidación-Reducción
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