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1.
J Exp Med ; 184(6): 2423-7, 1996 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-8976198

RESUMEN

IL-7R-deficient mice have severely impaired expansion of early lymphocytes and lack gamma delta T cells. To elucidate the role of IL-7R on gamma delta T cell development, we analyzed the rearrangements of TCR-alpha, beta, gamma, and delta genes in the thymus of the IL-7R-deficient mice. Southern blot analysis with a J gamma 1 probe revealed that more than 70% of J gamma 1 and J gamma 2 alleles are recombined to form distinct V gamma 1.2-J gamma 2 and V gamma 2-J gamma 1 fragments in control mice. On the contrary, no such recombination was detected in the mutant mice. The rearrangements in the TCR-alpha, beta, and delta loci were comparably observed in control and mutant mice. PCR analysis indicated that the V-J recombination of all the V gamma genes is severely hampered in the mutant mice. The mRNA of RAG-1, RAG-2, Ku-80, and terminal deoxynucleotidyl transferase (TdT) genes was equally detected between control and mutant thymi, suggesting that the expression of common recombination machinery is not affected. These data demonstrated that the V-J recombination of the TCR gamma genes is specifically blocked in the IL-7R-deficient mice and suggested the presence of highly specific regulation for TCR gamma gene rearrangement.


Asunto(s)
Antígenos CD/metabolismo , Proteínas de Unión al ADN , Reordenamiento Génico de la Cadena gamma de los Receptores de Antígenos de los Linfocitos T , Proteínas de Homeodominio , Receptores de Interleucina/metabolismo , Linfocitos T/inmunología , Animales , Antígenos CD/fisiología , Cartilla de ADN , Exones , Heterocigoto , Homocigoto , Región de Unión de la Inmunoglobulina/genética , Región Variable de Inmunoglobulina/genética , Ratones , Ratones Transgénicos , Fosfoglicerato Quinasa/biosíntesis , Fosfoglicerato Quinasa/genética , Reacción en Cadena de la Polimerasa , Biosíntesis de Proteínas , Receptores de Antígenos de Linfocitos T gamma-delta/biosíntesis , Receptores de Antígenos de Linfocitos T gamma-delta/genética , Receptores de Interleucina/fisiología , Receptores de Interleucina-7 , Recombinación Genética
2.
J Exp Med ; 187(11): 1779-88, 1998 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-9607919

RESUMEN

Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms. Unexpectedly, however, the PAF receptor-deficient mice developed normally, were fertile, and remained sensitive to bacterial endotoxin. These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock.


Asunto(s)
Anafilaxia/inmunología , Lipopolisacáridos/inmunología , Glicoproteínas de Membrana Plaquetaria/fisiología , Receptores de Superficie Celular , Receptores Acoplados a Proteínas G , Animales , Marcación de Gen , Corazón/fisiología , Homeostasis , Masculino , Ratones , Glicoproteínas de Membrana Plaquetaria/deficiencia , Glicoproteínas de Membrana Plaquetaria/genética , Reproducción , Choque Séptico/inmunología
3.
Cell Death Differ ; 14(5): 992-1000, 2007 May.
Artículo en Inglés | MEDLINE | ID: mdl-17218958

RESUMEN

Here, we describe the non-redundant roles of caspase-activated DNase (CAD) and DNasegamma during apoptosis in the immature B-cell line WEHI-231. These cells induce DNA-ladder formation and nuclear fragmentation by activating CAD during cytotoxic drug-induced apoptosis. Moreover, these apoptotic manifestations are accompanied by inhibitor of CAD (ICAD) cleavage and are abrogated by the constitutive expression of a caspase-resistant ICAD mutant. No such nuclear changes occur during oxidative stress-induced necrosis, indicating that neither CAD nor DNasegamma functions under necrotic conditions. Interestingly, the DNA-ladder formation and nuclear fragmentation induced by B-cell receptor ligation occur in the absence of ICAD cleavage and are not significantly affected by the ICAD mutant. Both types of nuclear changes are preceded by the upregulation of DNasegamma expression and are strongly suppressed by 4-(4,6-dichloro-[1, 3, 5]-triazin-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (DR396), which is a specific inhibitor of DNasegamma. Our results suggest that DNasegamma provides an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for CAD activation.


Asunto(s)
Apoptosis , Linfocitos B/citología , Linfocitos B/enzimología , Endodesoxirribonucleasas/genética , Endodesoxirribonucleasas/metabolismo , Perfilación de la Expresión Génica , Receptores de Antígenos de Linfocitos B/metabolismo , Animales , Proteínas Reguladoras de la Apoptosis/genética , Proteínas Reguladoras de la Apoptosis/metabolismo , Linfocitos B/efectos de los fármacos , Reactivos de Enlaces Cruzados/farmacología , Citotoxicidad Inmunológica/efectos de los fármacos , Fragmentación del ADN/efectos de los fármacos , Desoxirribonucleasas/genética , Desoxirribonucleasas/metabolismo , Activación Enzimática/efectos de los fármacos , Regulación Enzimológica de la Expresión Génica/efectos de los fármacos , Ratones , Proteínas Mutantes/metabolismo , Necrosis , Nucleosomas/efectos de los fármacos , Nucleosomas/metabolismo , Estrés Oxidativo/efectos de los fármacos , Regulación hacia Arriba/efectos de los fármacos
4.
Biochim Biophys Acta ; 1304(2): 161-9, 1996 Nov 22.
Artículo en Inglés | MEDLINE | ID: mdl-8954139

RESUMEN

In a previous study, we characterized prostanoid and thrombin receptors expressed on a megakaryoblastic cell line, MEG-01s (Blood 78, 2328-2336, 1991). In this study, we examines the mechanism of cross-talk between intracellular Ca2+ ([Ca2+]i) and cAMP signalings through prostanoid and thrombin receptors. Addition of a thromboxane (TX)A2 mimetic (U46619 or STA2) or thrombin stimulated the formation of inositol phosphates and dose-dependently augmented a prostaglandin (PG)I2 mimetic (iloprost)- or forskolin-induced cAMP formation. 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin, to lesser extent, also augmented iloprost-induced cAMP formation. The enhancing effect of U46619 or TPA on cAMP formation was inhibited by prolonged pretreatment of the cells with TPA (2.5 microM, 24 h), but not with calmodulin-antagonists; W-7, W-5, or KN-62. The elevation of [Ca2+]i induced by thrombin, STA2 or PGE2 was significantly suppressed by pretreatment of the cells with TPA (100 nM) as well as cAMP mimetics such as dibutyryl cAMP (5 mM), forskolin (5 microM) and iloprost (1 microM). These results suggest the key role of PKC on the cross-talk between [Ca2+]i and cAMP signalings through prostanoid and thrombin receptors; PKC, which is activated with TXA2 or thrombin, concomitantly suppress further [Ca2+]i elevation and enhances the PGI2 receptor-mediated cAMP formation, which, in turn, suppress [Ca2+]i elevation.


Asunto(s)
Células Madre Hematopoyéticas/fisiología , Megacariocitos/fisiología , Proteína Quinasa C/metabolismo , Receptores de Prostaglandina/metabolismo , Receptores de Trombina/metabolismo , 1-(5-Isoquinolinesulfonil)-2-Metilpiperazina/análogos & derivados , 1-(5-Isoquinolinesulfonil)-2-Metilpiperazina/farmacología , Ácido 15-Hidroxi-11 alfa,9 alfa-(epoximetano)prosta-5,13-dienoico , Calcio/metabolismo , Línea Celular , AMP Cíclico/metabolismo , Dinoprostona/farmacología , Humanos , Iloprost/farmacología , Ionomicina/farmacología , Endoperóxidos de Prostaglandinas Sintéticos/farmacología , Transducción de Señal , Sulfonamidas/farmacología , Acetato de Tetradecanoilforbol/farmacología , Trombina/farmacología , Tromboxano A2/análogos & derivados , Tromboxano A2/farmacología
5.
Transplantation ; 64(1): 152-7, 1997 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-9233716

RESUMEN

BACKGROUND: Data supporting the differential activation of T helper (Th) 2 cells in transplantation acceptance/tolerance in rodents have been presented by several investigators. However, the differential activation of Th2 cells may be simply the result of allograft acceptance/tolerance induction instead of a contribution to the maintenance of grafts. METHODS: Therefore, we established interleukin (IL)-4 transgenic mice under the control of a cardiac alpha-myosin heavy chain promotor and transplanted IL-4-expressing heart allografts into unmodified recipients to determine the actual contribution of the Th2 bias to allograft acceptance. RESULTS: Among 16 newborn C57BL/6J (B6) mice, three were positive for the IL-4 transgene. Serum IL-4 levels of transgenic versus control B6xC3H F1 mice were not statistically different. Reverse-transcriptase polymerase chain reaction showed that the transgenic B6xC3H F1 mice expressed IL-4 mRNA in the heart and in the lung, whereas control mice did not express IL-4 in any organ. IL-4 mRNA expression in the transgenic but not in the control heart was also confirmed by RNAse protection assay and fluorescence in situ hybridization. The survival of IL-4 transgenic B6xC3H heart grafts heterotopically placed in C3H recipients was prolonged compared with that of nontransgenic grafts (19.0+/-9.1 vs. 6.8+/-2.2 days, P=0.003). Interferon-gamma mRNA expression in IL-4 transgenic heart grafts on the fifth posttransplant day as assessed by Northern blotting was suppressed compared with that in control grafts. Reverse-transcriptase polymerase chain reaction analysis showed that IL-2 mRNA was suppressed in the IL-4 transgenic grafts compared with that in control grafts, while IL-4 mRNA was observed only in IL-4 transgenic grafts. IL-10 mRNA was detected at similar levels in both transgenic and control grafts. CONCLUSIONS: A Th2 bias may contribute to allograft acceptance in part by inducing the down-regulation of Th1-cytokine mRNAs, but it may not be sufficient to induce indefinite graft survival.


Asunto(s)
Citocinas/genética , Trasplante de Corazón/inmunología , Interleucina-4/fisiología , Animales , Regulación hacia Abajo , Femenino , Supervivencia de Injerto/efectos de los fármacos , Corazón/anatomía & histología , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Transgénicos , Miocardio/química , Miosinas/genética , Adhesión en Parafina , Regiones Promotoras Genéticas , ARN Mensajero/metabolismo , Bazo/química , Linfocitos T Colaboradores-Inductores/citología , Trasplante Homólogo/inmunología
6.
Thromb Haemost ; 79(6): 1106-10, 1998 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9657432

RESUMEN

To evaluate thrombopoiesis in thrombocytopenic disorders, we simultaneously determined reticulated platelet counts in whole blood by FACScan flow cytometry and serum thrombopoietin (TPO) concentrations by a sensitive sandwich ELISA. The subjects were 40 healthy volunteers and 45 thrombocytopenic patients. In idiopathic thrombocytopenic purpura (ITP), the percentage of reticulated platelets was significantly elevated (5.61 +/- 2.02%: mean +/- SD) relative to normal controls (2.17 +/- 0.90%), but serum TPO concentrations (1.91 +/- 1.27 fmol/l) did not differ significantly from the normal range (1.43 +/- 0.62 fmol/l). The patients with aplastic anemia (AA) had decreased reticulated platelet counts and markedly increased serum TPO concentrations (13.65 +/- 10.64 fmol/l). In thrombocytopenic patients with liver cirrhosis (LC), the absolute number of reticulated platelets (1.65 +/- 1.11 x 10(9)/l) decreased similarly that in AA. However, serum TPO concentrations (1.38 +/- 0.50 fmol/l) did not increase in contrast to AA. Our findings suggested a possible dual mechanism of thrombocytopenia in LC; that is, thrombocytopenia in LC results from the decreased TPO production primarily in the liver adding to an increase in platelet sequestration in the spleen.


Asunto(s)
Hematopoyesis , Recuento de Plaquetas , Trombocitopenia/fisiopatología , Trombopoyetina/sangre , Anemia Aplásica/sangre , Anemia Aplásica/complicaciones , Enfermedades Autoinmunes/sangre , Enfermedades Autoinmunes/fisiopatología , Biomarcadores , Plaquetas/ultraestructura , Médula Ósea/patología , Ensayo de Inmunoadsorción Enzimática , Humanos , Cirrosis Hepática/sangre , Cirrosis Hepática/complicaciones , Pruebas de Función Hepática , Megacariocitos/patología , Leucemia-Linfoma Linfoblástico de Células Precursoras/sangre , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicaciones , Púrpura Trombocitopénica Idiopática/sangre , Púrpura Trombocitopénica Idiopática/fisiopatología , Trombocitopenia/sangre , Trombocitopenia/etiología
7.
J Cancer Res Clin Oncol ; 123(11-12): 619-22, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9620220

RESUMEN

The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leukemic cell line (HL-60), which showed higher sensitivity to H2O2. Pretreatment of these cell lines with L-buthionine-[S,R]-sulfoximine, which significantly reduced the intracellular GSH concentration, increased their sensitivity against H2O2, whereas pretreatment with N-acetyl-L-cysteine, which did not significantly change the intracellular GSH concentration, only marginally protected the cells from the cytotoxic effect of H2O2. The results suggest that drug sensitivity of tumor cells can be modified by glutathione-modulating compounds.


Asunto(s)
Acetilcisteína/farmacología , Butionina Sulfoximina/farmacología , Glioblastoma/patología , Glioma/patología , Peróxido de Hidrógeno/farmacología , Supervivencia Celular/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Inhibidores Enzimáticos/farmacología , Depuradores de Radicales Libres/farmacología , Glioblastoma/química , Glioma/química , Glutatión/análisis , Humanos , Células Tumorales Cultivadas
8.
Anticancer Res ; 17(4A): 2407-10, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9252655

RESUMEN

Sodium ascorbate, sodium 5,6-benzylidene-L-ascorbate (SBA), gallic acid and caffeic acid induced apoptotic cell death in human myelogenous leukemic cell lines, and stimulated oxidation of methionine into methionine sulfoxide in the culture medium. When various tumor cell lines were cultured in methionine-free medium, their growth was nearly terminated at G1 phase of the cell cycle, producing much smaller number of apoptotic cells. Addition of methionine sulfoxide to the methionine-free medium did not stimulate the apoptosis induction. These data suggest that induction of apoptosis by ascorbates, gallate or by caffeate cannot be simply explained by methionine oxidation.


Asunto(s)
Apoptosis , División Celular , Metionina/metabolismo , Células Tumorales Cultivadas/citología , Antioxidantes/química , Ácido Ascórbico/química , ADN de Neoplasias/genética , Citometría de Flujo , Radicales Libres , Humanos , Metionina/análogos & derivados , Metionina/química , Oxidación-Reducción
9.
Int J Oral Maxillofac Surg ; 24(4): 298-300, 1995 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-7490494

RESUMEN

The Kabuki make-up syndrome is characterized by peculiar cranio-facial abnormalities, including cleft lip and palate. A case with velopharyngeal incompetence in a 7-year-old boy is reported. The significance of a possible association of this syndrome with congenital velopharyngeal incompetence is also discussed.


Asunto(s)
Cara/anomalías , Insuficiencia Velofaríngea/congénito , Anomalías Múltiples , Niño , Enanismo/patología , Humanos , Discapacidad Intelectual , Masculino , Maloclusión de Angle Clase III/patología , Hueso Paladar/anomalías , Trastornos del Habla/patología , Síndrome , Úvula/anomalías
10.
J Vet Med Sci ; 58(4): 369-72, 1996 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-8741273

RESUMEN

An ELISA test for the detection of antibody against S. suis type 2 in pigs was developed and applied to field sera. The best sensitivity and specificity of ELISA were obtained when a purified polysaccharide antigen was used. It showed no cross reaction with sera against other serotypes of S. suis and other pathogenic bacteria. A total of 264 sera were collected from 20 pig farms and examined with the antibody against S. suis type 2. In the affected farms, 17.0% of pigs tested were positive, 9.8% in the adjacent farms, but only 3.4% in the free farms. The difference of the positive percentages between the affected and the free farms was statistically significant (P < 0.05).


Asunto(s)
Anticuerpos Antibacterianos/sangre , Infecciones Estreptocócicas/veterinaria , Streptococcus suis , Enfermedades de los Porcinos , Animales , Ensayo de Inmunoadsorción Enzimática/métodos , Ensayo de Inmunoadsorción Enzimática/veterinaria , Polisacáridos Bacterianos/inmunología , Valor Predictivo de las Pruebas , Valores de Referencia , Sensibilidad y Especificidad , Infecciones Estreptocócicas/diagnóstico , Infecciones Estreptocócicas/inmunología , Streptococcus suis/inmunología , Porcinos
11.
No Shinkei Geka ; 27(3): 225-31, 1999 Mar.
Artículo en Japonés | MEDLINE | ID: mdl-10190156

RESUMEN

Micro-pressure-suction-irrigation system (MPSIS), introduced by Luedecke et al, is an instrumentation for the direct transnasal pituitary procedure. We improved this system for use in Japan. The irrigation system can effectively clean the operating field by one-hand manipulation and dissect tumor tissue by its rapid flow. The pressure of suction and irrigation can be adjusted respectively by a device in the handpiece. The MPSIS is applicable to different stages of intervention because it is equipped with separate tips of various diameters, lengths and angles. This system is especially useful in combination with a micromirror or an endoscopy for direct inspection of the eccentric tumor sites such as the cavernous sinus, the upper part of the planum sphenoidale, or the posterior suprasellar regions. The use of the MPSIS helps to avoid injury to normal tissue structures, and prevents tiny soft microadenoma from being lost during preparation. We have proved the suitability and usefulness of the MPSIS in 23 surgical interventions for transnasal microsurgery of pituitary adenomas.


Asunto(s)
Adenoma/cirugía , Hipofisectomía/instrumentación , Hipofisectomía/métodos , Microcirugia/instrumentación , Neoplasias Hipofisarias/cirugía , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Presión , Succión , Irrigación Terapéutica/instrumentación
12.
Rinsho Ketsueki ; 32(2): 170-2, 1991 Feb.
Artículo en Japonés | MEDLINE | ID: mdl-2027243

RESUMEN

Natural interferon-alpha (IFN-alpha) alone was administered to a 42-year-old man with acute leukemia, whose bone marrow revealed hypocellularity (NCC = 6 X 10(4)/microliters) and a 50% increase in blasts. Initial chemotherapy regimens, including BHAC-DMP or low dose Ara-C were ineffective. One month after starting nIFN-alpha therapy, the blasts in his bone marrow decreased below 3% and peripheral blood cell counts became normal. He has been in remission for at least 7 months.


Asunto(s)
Interferón Tipo I/uso terapéutico , Leucemia/terapia , Enfermedad Aguda , Adulto , Humanos , Masculino
13.
No To Shinkei ; 51(4): 353-9, 1999 Apr.
Artículo en Japonés | MEDLINE | ID: mdl-10363272

RESUMEN

The incidence of metastatic brain tumors is increasing because of the recent progress in the detection and management of primary cancer. However, metastatic skull tumors from cancers associated with giant subcutaneous mass lesions are rare. We present four patients with metastatic skull tumors: two from hepatic cancer, one from lung cancer, and one from mamma cancer. In these patients, plain skull X-ray and bone CT showed osteolytic lesions. Angiograms revealed a tumor stain fed by abnormal vessels from the external carotid artery. MRI demonstrated masses with marked homogeneous enhancement with the "dural tail sign" in the dura adjacent to the tumors in three skull tumors from hepatic and mamma cancers, and a mass with slightly enhancement without the "dural tail sign" in a skull tumor from lung cancer. At surgery, hemorrhagic well-demarcated tumors were totally removed. The histological diagnosis was skull metastases from cancers in all cases. In cases with the "dural tail sign" on MRI, no tumor cells were seen in the inner layer of the dura and the dura adjacent to the tumors. It is possible that the "dural tail" is due to increased vascular permeability of the dural vessels. The recurrence of these skull tumors was not observed during the follow-up period. Surgical treatment for the metastatic skull tumors from cancers may be indicated to prevent deteriorating neurological symptoms affecting the quality of life.


Asunto(s)
Neoplasias Craneales/secundario , Adenocarcinoma/diagnóstico , Adenocarcinoma/secundario , Adenocarcinoma/cirugía , Adulto , Anciano , Neoplasias de la Mama/patología , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/secundario , Carcinoma Hepatocelular/cirugía , Angiografía Cerebral , Femenino , Humanos , Neoplasias Hepáticas/patología , Neoplasias Pulmonares/patología , Imagen por Resonancia Magnética , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Neoplasias Craneales/diagnóstico , Neoplasias Craneales/cirugía , Tomografía Computarizada por Rayos X
14.
Rinsho Ketsueki ; 41(1): 68-71, 2000 Jan.
Artículo en Japonés | MEDLINE | ID: mdl-10695403

RESUMEN

In March 1990, a 61-year-old man was given a diagnosis of essential thrombocythemia with a normal karyotype and subsequently treated with hydroxyurea. In November 1995, he underwent surgery for gastric cancer with thereafter received tegafur/uracil for 2 years. Refractory anemia with excess of blasts in transformation and chromosomal abnormalities including -5, -7, 20q-developed in August 1998. Combined chemotherapy with daunorubicin, cytarabine, mercaptopurine, and prednisolone, had only limited effectiveness. Acute myeloid leukemia was finally diagnosed in October 1998, and chromosomal analysis disclosed inv(3) in addition to -5 and -7. The appearance of inv(3) might be related to leukemic transformation of hematopoietic stem cell disease with an increase in the number of megakaryocytes and platelets.


Asunto(s)
Inversión Cromosómica , Cromosomas Humanos Par 3/genética , Leucemia Mieloide Aguda/patología , Síndromes Mielodisplásicos/patología , Neoplasias Primarias Secundarias , Neoplasias Gástricas , Trombocitemia Esencial/complicaciones , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Resultado Fatal , Gastrectomía , Humanos , Hidroxiurea/uso terapéutico , Cariotipificación , Leucemia Mieloide Aguda/genética , Masculino , Neoplasias Gástricas/terapia , Tegafur/administración & dosificación , Trombocitemia Esencial/tratamiento farmacológico , Uracilo/administración & dosificación
20.
Cancer ; 70(8): 2105-8, 1992 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-1394040

RESUMEN

BACKGROUND: A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown. METHODS: The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, enzyme-linked immunosorbent assay and immunohistochemical analysis were used. RESULTS: Tumor cells produced large amounts of interleukin-6 (IL-6) and small amounts of granulocyte macrophage colony stimulating factor (GM-CSF) and monocyte colony stimulating factor (M-CSF). Immunocytochemical staining of tumor cells showed strong positivity for IL-6. CONCLUSIONS: These results indicated that persistent secretion of IL-6 promoted thrombogenesis in this patient.


Asunto(s)
Interleucina-6/metabolismo , Mesotelioma/metabolismo , Neoplasias Peritoneales/metabolismo , Trombocitosis/etiología , Humanos , Masculino , Mesotelioma/complicaciones , Mesotelioma/patología , Persona de Mediana Edad , Neoplasias Peritoneales/complicaciones , Neoplasias Peritoneales/patología
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