Examining the generalizability of research findings from archival data.

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability-for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples.

Design and simulation of a cross-regional collaborative recycling system for secondary resources: A case of lead-acid batteries.

In emerging economies, a significant amount of secondary resources are recycled by the informal sector, which can seriously harm the environment. However, some previous studies of industry management policy design ignored geographical factors. This paper introduces Geographic Information Systems into an agent-based cross-regional recycling model, and employs lead-acid batteries as an example. The model quantitatively displays the evolution of recycling markets in 31 provinces in Mainland China. Results show that: (1) High subsidies can significantly increase the number of formal enterprises in the short term, but their effectiveness decreases when the proportion of government funds in subsidies is above 80% in the long run; (2) The number of illegal recycling enterprises increases by 294% in eight inland provinces (e.g., Ningxia, Xinjiang) when all funds are invested in supervision, but this number is quite small in subsidy policy scenarios; (3) In four eastern regions, including Beijing and Tianjin, the number of illegal recycling enterprises decreases by 84% if supervision is more favored than subsidy; (4) In the optimal case where spatiotemporal factors are considered in all 31 regions, illegal recycling enterprises and waste lead emissions can be reduced by 95.59% and 45.85% nationwide. Our proposed recycling model offers a detailed simulation of multiple regions and diverse stakeholders, and serves as a useful reference for targeted recovery policies. Governments in inland regions like Ningxia and Xinjiang should implement subsidy policies, while supervision policies should be implemented in developed regions like Beijing and Tianjin.

Impact of Hydrostatic Pressure on Molecular Structure and Dynamics of the Sodium and Chloride Ions in Portlandite Nanopores.

In order to address the issues of energy depletion, more resources are being searched for in the deep sea. Therefore, research into how the deep-sea environment affects cement-based materials for underwater infrastructure is required. This paper examines the impact of ocean depth (0, 500, 1000, and 1500 m) on the ion interaction processes in concrete nanopores using molecular dynamics simulations. At the portlandite interface, the local structural and kinetic characteristics of ions and water molecules are examined. The findings show that the portlandite surface hydrophilicity is unaffected by increasing depth. The density profile and coordination number of ions alter as depth increases, and the diffusion speed noticeably decreases. The main cause of the ions' reduced diffusion velocity is expected to be the low temperature. This work offers a thorough understanding of the cement hydration products' microstructure in deep sea, which may help explain why cement-based underwater infrastructure deteriorates over time.

Low temperature and highly-efficient one-step decomposition of phosphogypsum via biochar by Fe3+/Co2+/Ni2+ unitary/ternary catalyst.

Phosphogypsum (PG), which has great environmental harm and restricts the sustainable development of phosphorus chemical industry, is a solid waste produced in phosphoric acid production. Thermal decomposition of PG is an extensive way to reutilization of resource, and the key point is to establish an appropriate decomposition path and catalyst system of PG. In the work, the strategy for low-temperature and highly-efficient decomposition of PG is established based on the thermodynamic analysis and the experimental research by metal ions to reduce the decomposition temperature. Meanwhile, SEM(Scanning Electron Microscope) is used to characterize the composition and morphology of PG in the various conditions, also the decomposition temperature is analyzed by TGA(Thermogravimetric Analysis). Then, the decomposition ratio via Fe3+/Co2+/Ni2+ unitary/ternary catalyst is obtained by precipitation method. Through kinetic analysis combined with XRF(X-ray Fluorescence Spectrometer) and EDX(Energy Dispersive X-Ray Spectroscopy) results, it is found that there is a reaction competition in the decomposition process by Fe3+/Co2+/Ni2+ ternary catalyst. Further the mechanism of catalytic system on PG is derived. The present work can be concluded that Fe3+/Co2+/Ni2+ can effectively reduce the decomposition temperature of PG, and the effect of ternary metal is more obvious than that of unitary metal. Finally, pomelo peel is used instead of coke to successfully decompose PG at low temperature by one step method. The establishment of low temperature decomposition system of PG has potential application in phosphorus chemical industry and is in line with sustainable development.

The study on the effect of flotation purification on the performance of α-hemihydrate gypsum prepared from phosphogypsum.

Phosphogypsum (PG) is a massive industrial solid waste. In this paper, PG was purified by flotation method, and α-hemihydrate gypsum (α-HH) was prepared by the autoclaving method. The morphology of α-HH was adjusted by adding different doses of Maleic acid and Aluminium sulfate. The results showed that after flotation purification, the impurity content in PG was significantly reduced, the soluble phosphorus content decreased from 0.48 to 0.07%, the PG purity increased from 73.12 to 94.37%, and the PG whiteness risen from 19.4 to 40.5. Then the performance of α-HH prepared from PG before and after purification was compared. Fixing the amount of aluminium sulfate at 0.2 wt%, the reaction temperature at 140 °C, and the reaction time at 120 min, the average length/diameter ratio of α-HH crystals decreased from 7.2 to 0.6 as the amount of Maleic acid increased from 0 to 0.17 wt%. When the amount of Maleic acid was 0.13 wt%, the α-hemihydrate gypsum reached the best mechanical properties. The mechanical strength of high strength gypsum prepared from PG concentrate was significantly better than that of raw PG, indicating that flotation purification can effectively improve the performance of PG. In this study, a new method of PG purification and resource utilization was proposed.

RNA Sequencing Reveals Dynamic Carbohydrate Metabolism and Phytohormone Signaling Accompanying Post-mowing Regeneration of Forage Winter Wheat (Triticum aestivum L.).

Winter wheat (Triticum aestivum L.) is used as fresh green winter forage worldwide, and its ability to regenerate after mowing determines whether it can be used for forage production; however, the molecular mechanism of regeneration is poorly understood. This study identified long-chain coding and non-coding RNAs in the wheat cultivar "XN9106," which is cultivated for forage and grain production separately in winter and summer, and analyzed their function during post-mowing regeneration. The results showed that the degradation of carbohydrate plays an important role in regeneration, as demonstrated by decreased carbohydrate content. The increased gene expression of enzymes including ß-amylase, ß-fructofuranosidase, sucrose synthase, sucrose-6-phosphate synthase, trehalose-6-phosphate synthase, and trehalose-6-phosphate phosphatase in mowed seedlings suggests regeneration is fueled by degraded carbohydrates that provide energy and carbon skeletons for the Krebs cycle and amino acid synthesis. The decreased auxin content relieved the inhibition of cytokinin synthesis, that controls the transition from cell division to cell expansion and stimulates cell expansion and differentiation during the cell expansion phase, and eventually accelerate post-mowing regeneration of seedlings. Additionally, differentially expressed long-chain non-coding RNAs (lncRNAs) might participate in the regulation of gene expression related to carbohydrate metabolism and hormone signal transduction. This study demonstrated the responses of key mRNAs and lncRNAs during post-mowing regeneration of winter wheat and revealed the importance of carbohydrate and hormone during regeneration, providing valuable information for genetic improvement of forage wheat.

Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products.

BACKGROUND AND PURPOSE: Advanced glycation end products (AGEs) and endothelial progenitor cells (EPCs) play key roles in pathogenesis of diabetes-related vascular complications. AGEs can induce dysfunction in EPCs. The peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists are widely used in the treatment of type 2 diabetes, and it remains unknown if they could attenuate EPC dysfunction induced by AGEs. EXPERIMENTAL APPROACH: EPCs isolated from healthy adults were cultured with various concentrations of AGEs (0, 50, 100 and 200 mg L(-1)) with or without rosiglitazone (10 nM), antibody for the receptors for AGE-human serum albumin (anti-receptor for advanced glycation end products (RAGE); 50 microg mL(-1)), phosphatidylinositol-3-kinase (PI3K) inhibitor (LY294002, 5 microM), nitric oxide (NO) synthase inhibitor (L-N(G)-nitro-arginine methyl ester (L-NAME), 100 microM) or sodium nitroprusside (SNP, 25 microM). Proliferation, apoptosis, cell adhesion, migration and NO production in EPCs were assessed, and expressions of endothelial NO synthase (eNOS) and Akt were determined. KEY RESULTS: Number, proliferation/migration capacities, eNOS and Akt phosphorylation as well as NO synthesized by EPCs were increased by rosiglitazone and reduced by AGEs. AGEs promoted while rosiglitazone reduced EPC apoptosis. The AGE-induced effects were significantly ameliorated by pre-incubation with rosiglitazone, RAGE antibody and SNP. The beneficial effects of rosiglitazone could be blocked by pretreatment with L-NAME and LY294002. CONCLUSIONS AND IMPLICATIONS: The PPARgamma agonist rosiglitazone increased EPC function and attenuated EPC dysfunction induced by AGEs via upregulating the Akt-eNOS signal pathways of EPCs.