Búsqueda | Biblioteca Virtual en Salud Fronteriza

1.

Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation.

Yong, Jun; Toh, Cheng-Hock.

Blood ; 142(25): 2133-2145, 2023 12 21.

Artículo en Inglés | MEDLINE | ID: mdl-37890148

2.

Shades of Grey-The brain in TTP.

Dutt, Tina; Toh, Cheng-Hock.

Br J Haematol ; 204(3): 757-758, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38228136

3.

Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation.

Abrams, Simon T; Su, Dunhao; Sahraoui, Yasmina; Lin, Ziqi; Cheng, Zhenxing; Nesbitt, Kate; Alhamdi, Yasir; Harrasser, Micaela; Du, Min; Foley, Jonathan H; Lillicrap, David; Wang, Guozheng; Toh, Cheng-Hock.

Blood ; 137(1): 103-114, 2021 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-33410894

4.

Real-world experience with caplacizumab in the management of acute TTP.

Dutt, Tina; Shaw, Rebecca J; Stubbs, Matthew; Yong, Jun; Bailiff, Benjamin; Cranfield, Tanya; Crowley, Maeve P; Desborough, Michael; Eyre, Toby A; Gooding, Richard; Grainger, John; Hanley, John; Haughton, Joanna; Hermans, Joannes; Hill, Quentin; Humphrey, Louise; Lowe, Gillian; Lyall, Hamish; Mohsin, Muhammad; Nicolson, Phillip L R; Priddee, Nicole; Rampotas, Alexandros; Rayment, Rachel; Rhodes, Susan; Taylor, Alice; Thomas, William; Tomkins, Oliver; Van Veen, Joost J; Lane, Steven; Toh, Cheng-Hock; Scully, Marie.

Blood ; 137(13): 1731-1740, 2021 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-33150355

5.

Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis.

Abrams, Simon T; Alhamdi, Yasir; Zi, Min; Guo, Fengmei; Du, Min; Wang, Guozheng; Cartwright, Elizabeth J; Toh, Cheng-Hock.

Int J Mol Sci ; 24(4)2023 Feb 06.

Artículo en Inglés | MEDLINE | ID: mdl-36834636

6.

Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis.

Cheng, Zhenxing; Abrams, Simon T; Toh, Julien; Wang, Susan S; Downey, Colin; Ge, Xiaoling; Yu, Qian; Yu, Weiping; Wang, Guozheng; Toh, Cheng-Hock.

J Immunol ; 204(10): 2712-2721, 2020 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-32269097

7.

Tranexamic acid for safer surgery: the time is now.

Grocott, Michael P W; Murphy, Mike; Roberts, Ian; Sayers, Rob; Toh, Cheng-Hock.

Br J Anaesth ; 129(4): 459-461, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-36070986

8.

Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis.

Alsabani, Mohmad; Abrams, Simon T; Cheng, Zhenxing; Morton, Ben; Lane, Steven; Alosaimi, Samar; Yu, Weiping; Wang, Guozheng; Toh, Cheng-Hock.

Br J Anaesth ; 128(2): 283-293, 2022 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-34893315

9.

COVID-19 and immunothrombosis: emerging understanding and clinical management.

Shaw, Rebecca J; Bradbury, Charlotte; Abrams, Simon T; Wang, Guozheng; Toh, Cheng-Hock.

Br J Haematol ; 194(3): 518-529, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-34114204

10.

Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England.

Allard, Shubha; Cort, Jon; Howell, Catherine; Sherliker, Louise; Miflin, Gail; Toh, Cheng Hock.

Transfus Med ; 31(6): 400-408, 2021 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-34693582

11.

Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4.

Qaddoori, Yasir; Abrams, Simon T; Mould, Paul; Alhamdi, Yasir; Christmas, Stephen E; Wang, Guozheng; Toh, Cheng-Hock.

J Immunol ; 200(12): 4125-4133, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29752310

12.

A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients.

Abrams, Simon T; Morton, Ben; Alhamdi, Yasir; Alsabani, Mohmad; Lane, Steven; Welters, Ingeborg D; Wang, Guozheng; Toh, Cheng-Hock.

Am J Respir Crit Care Med ; 200(7): 869-880, 2019 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-31162936

13.

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development.

Cheng, Zhenxing; Abrams, Simon T; Austin, James; Toh, Julien; Wang, Susan Siyu; Wang, Zhi; Yu, Qian; Yu, Weiping; Toh, Cheng Hock; Wang, Guozheng.

Mediators Inflamm ; 2020: 7418342, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-32934605

14.

Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.

Cheng, Zhenxing; Abrams, Simon T; Alhamdi, Yasir; Toh, Julien; Yu, Weiping; Wang, Guozheng; Toh, Cheng-Hock.

Crit Care Med ; 47(8): e677-e684, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31162199

15.

The Health and Care Act 2022: challenges and priorities for embedding research in the NHS.

Toh, Cheng Hock; Haynes, Richard.

Lancet ; 400(10349): 343-345, 2022 07 30.

Artículo en Inglés | MEDLINE | ID: mdl-35809580

16.

Tranexamic acid for safer surgery: does the evidence support preventative use? Response to Br J Anaesth 2023; 130: e23-e24.

Grocott, Michael P W; Murphy, Mike; Roberts, Ian; Sayers, Rob; Toh, Cheng-Hock.

Br J Anaesth ; 130(2): e195-e196, 2023 02.

Artículo en Inglés | MEDLINE | ID: mdl-36522217

17.

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection.

Alhamdi, Yasir; Neill, Daniel R; Abrams, Simon T; Malak, Hesham A; Yahya, Reham; Barrett-Jolley, Richard; Wang, Guozheng; Kadioglu, Aras; Toh, Cheng-Hock.

PLoS Pathog ; 11(5): e1004836, 2015 May.

Artículo en Inglés | MEDLINE | ID: mdl-25973949

18.

Tranexamic acid for safer surgery: the time is now.

Grocott, Michael P W; Murphy, Mike; Roberts, Ian; Sayers, Rob; Toh, Cheng-Hock.

Br J Surg ; 109(12): 1182-1183, 2022 11 22.

Artículo en Inglés | MEDLINE | ID: mdl-36058554

19.

Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis.

Szatmary, Peter; Liu, Tingting; Abrams, Simon T; Voronina, Svetlana; Wen, Li; Chvanov, Michael; Huang, Wei; Wang, Guozheng; Criddle, David N; Tepikin, Alexey V; Toh, Cheng-Hock; Sutton, Robert.

Pancreatology ; 17(6): 884-892, 2017.

Artículo en Inglés | MEDLINE | ID: mdl-29102149

20.

The role of extracellular histones in haematological disorders.

Alhamdi, Yasir; Toh, Cheng-Hock.

Br J Haematol ; 173(5): 805-11, 2016 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-27062156

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Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation.

Shades of Grey-The brain in TTP.

Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation.

Real-world experience with caplacizumab in the management of acute TTP.

Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis.

Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis.

Tranexamic acid for safer surgery: the time is now.

Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis.

COVID-19 and immunothrombosis: emerging understanding and clinical management.

Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England.

Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4.

A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients.

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development.

Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.

The Health and Care Act 2022: challenges and priorities for embedding research in the NHS.

Tranexamic acid for safer surgery: does the evidence support preventative use? Response to Br J Anaesth 2023; 130: e23-e24.

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection.

Tranexamic acid for safer surgery: the time is now.

Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis.

The role of extracellular histones in haematological disorders.