[The effect of vitamin C on the lipolytic activity in type-II diabetics with angiopathy]. / "Efecto de la vitamina C sobre la actividad lipolítica en pacientes diabéticos tipo II con angiopatía".

Effects produced by different doses of Vit C (2, 3 and 4 gr/day) on lipoprotein and hepatic lipase activities were studied between a group of 35 ambulatory patients, men and women, affected by diabetes mellitus type II with macroangiopathy at lower limbs and/or food. The medium age of patients was 62 years, ranging from 44 to 82 years. Patients were aleatory divided into four groups. One from those four groups was treated with placebo, the other three received Vit C. In the group treated with 3 gr./day of Vit C we found a significant reduction and increase (p less than 0.05) of lipoprotein and hepatic lipase activities, respectively, when we compared outcomes before and after eight weeks of treatment with Vit C. By other hand, when we compared the different groups, we found a significant increase in the hepatic lipase activity in the same group, particularly between the patients whose plasmatic Vit C levels before treatment were reduced. We didn't found any significant change in the rest of parameters.

Lipidos sanguineos, intolerancia a los hidratos de carbono y macroarteriopatia de la edad senil. / Blood lipids, intolerance to carbon hydrates and macroarteriopathy of senile age

En un grupo de 47 pacientes de la consulta externa del Instituto de Angiologia, clasificados en diabeticos seniles que se tratan con tolbutamida mas dieta, diabeticos seniles que se tratan con dieta solamente, y pacientes no diabeticos con tolbutamida mas dieta: diabeticos seniles que se tratan con dieta solamente, y pacientes no diabeticos que presentan arteriopatias oclusivas de los miembros inferiores, todos los sexos masculinos y con 65 anos o mas, se les practico glicemia, colesterol total, trigliceridos y HDL/colesterol, 2 horas despues de ingerir un desayuno que contenia 180 g de hidratos de carbono. Se realizo un estudio analitico de varianza y un test de Tukey (para las glicemias) y no se encontraron diferencias significativas en los valores de lipidos de los tres grupos al compararse los valores entre si estas fueron significativos (p < 0,001) en los valores de glicemia entre grupos de diabeticos seniles y los no diabeticos que presentaban arteriopatias oclusivas de los miembros inferiores