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1.
Chemphyschem ; 18(13): 1773-1781, 2017 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-28125160

RESUMEN

We describe a chemical XOR gate design that realizes gate-response function with filtering properties. Such gate-response function is flat (has small gradients) at and in the vicinity of all the four binary-input logic points, resulting in analog noise suppression. The gate functioning involves cross-reaction of the inputs represented by pairs of chemicals to produce a practically zero output when both are present and nearly equal. This cross-reaction processing step is also designed to result in filtering at low output intensities by canceling out the inputs if one of the latter has low intensity compared with the other. The remaining inputs, which were not reacted away, are processed to produce the output XOR signal by chemical steps that result in filtering at large output signal intensities. We analyze the tradeoff resulting from filtering, which involves loss of signal intensity. We also discuss practical aspects of realizations of such XOR gates.

2.
Chemphyschem ; 18(20): 2908-2915, 2017 Oct 19.
Artículo en Inglés | MEDLINE | ID: mdl-28745425

RESUMEN

We report an experimental realization of a biochemical XOR gate function that avoids many of the pitfalls of earlier realizations based on biocatalytic cascades. Inputs-represented by pairs of chemicals-cross-react to largely cancel out when both are nearly equal. The cross-reaction can be designed to also optimize gate functioning for noise handling. When not equal, the residual inputs are further processed to result in the output of the XOR type, by biocatalytic steps that allow for further gate-function optimization. The quality of the realized XOR gate is theoretically analyzed.


Asunto(s)
Alcohol Deshidrogenasa/metabolismo , Oxidorreductasas de Alcohol/metabolismo , Biocatálisis , Glucosa Oxidasa/metabolismo , Hexoquinasa/metabolismo , NAD/metabolismo , Peroxidasa/metabolismo , Armoracia/enzimología , Aspergillus niger/enzimología , Modelos Moleculares , Pichia/enzimología , Saccharomyces cerevisiae/enzimología
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