RESUMEN
The spray drying technique was used to obtain the roxithromycin containing microcapsules with high taste masking efficiency. Eudragit L30D-55 was chosen as a barrier coating. The taste was evaluated by an electronic tongue, and taste-masking effect in water lasted at least several dozen hours.
Asunto(s)
Antibacterianos/química , Técnicas Biosensibles , Desecación , Enmascaramiento Perceptual , Roxitromicina/química , Percepción del Gusto , Gusto , Tecnología Farmacéutica/métodos , Aerosoles , Técnicas Biosensibles/instrumentación , Química Farmacéutica , Composición de Medicamentos , Humanos , Electrodos de Iones Selectos , Microscopía Electrónica de Rastreo , Análisis de Componente Principal , Propiedades de Superficie , Tecnología Farmacéutica/instrumentaciónRESUMEN
The pilosebaceous unit is a complex structure that undergoes a specific growth cycle and comprises a few important drug targeting sites. For example, drugs can be targeted to the bulge region with stem cells or to the sebaceous glands. Interest in pilosebaceous units is directed towards their utilization as reservoirs for localized therapy and also as a transport pathway for systemic drug delivery. Improved investigative methods, such as differential stripping, are being developed in order to determine follicular penetration. This article reviews relevant aspects of effective follicle-targeting formulations and delivery systems as well as the activity status of hair follicles, and variations in follicle size and distribution throughout various body regions. Each of these factors strongly affects follicular permeation. We provide examples of improved penetration of particle-based formulations and of a size-dependent manner of follicular penetration. Contradictions are also discussed, indicating the need for detailed future investigations.
Asunto(s)
Marcación de Gen/tendencias , Folículo Piloso , Animales , Sistemas de Liberación de Medicamentos/métodos , Folículo Piloso/anatomía & histología , Folículo Piloso/fisiología , Humanos , PermeabilidadRESUMEN
Electronic tongues can produce chemical images of samples, whose changes can be correlated with general properties, e.g. taste sensations. In this work, a sensor array equipped with eight types of ion-selective electrodes was coupled with Principal Components Analysis in order to detect microencapsulation effect of two Active Pharmaceutical Ingredients (APIs), which influences their taste properties. The character of change of sensor array responses in samples modified by microencapsulation was the same in two investigated APIs (Ibuprofen and Rixithromycin), proving, that the "sensed taste" becomes similar in both formulations after Eudragit modification. The obtained results show, that the presented electronic tongue can be used for analysis of masking effects in drugs and detection of microencapsulation effect.