Fast iterative tomographic wavefront estimation with recursive Toeplitz reconstructor structure for large-scale systems.

Tomographic wavefront reconstruction is the main computational bottleneck to realize real-time correction for turbulence-induced wavefront aberrations in future laser-assisted tomographic adaptive-optics (AO) systems for ground-based giant segmented mirror telescopes because of its unprecedented number of degrees of freedom, N, i.e., the number of measurements from wavefront sensors. In this paper, we provide an efficient implementation of the minimum-mean-square error (MMSE) tomographic wavefront reconstruction, which is mainly useful for some classes of AO systems not requiring multi-conjugation, such as laser-tomographic AO, multi-object AO, and ground-layer AO systems, but is also applicable to multi-conjugate AO systems. This work expands that by Conan [Proc. SPIE9148, 91480R (2014)PSISDG0277-786X10.1117/12.2054472] to the multi-wavefront tomographic case using natural and laser guide stars. The new implementation exploits the Toeplitz structure of covariance matrices used in an MMSE reconstructor, which leads to an overall O(N log N) real-time complexity compared with O(N2) of the original implementation using straight vector-matrix multiplication. We show that the Toeplitz-based algorithm leads to 60 nm rms wavefront error improvement for the European Extremely Large Telescope laser-tomography AO system over a well-known sparse-based tomographic reconstruction; however, the number of iterations required for suitable performance is still beyond what a real-time system can accommodate to keep up with the time-varying turbulence.

Multi time-step wavefront reconstruction for tomographic adaptive-optics systems.

In tomographic adaptive-optics (AO) systems, errors due to tomographic wavefront reconstruction limit the performance and angular size of the scientific field of view (FoV), where AO correction is effective. We propose a multi time-step tomographic wavefront reconstruction method to reduce the tomographic error by using measurements from both the current and previous time steps simultaneously. We further outline the method to feed the reconstructor with both wind speed and direction of each turbulence layer. An end-to-end numerical simulation, assuming a multi-object AO (MOAO) system on a 30 m aperture telescope, shows that the multi time-step reconstruction increases the Strehl ratio (SR) over a scientific FoV of 10 arc min in diameter by a factor of 1.5-1.8 when compared to the classical tomographic reconstructor, depending on the guide star asterism and with perfect knowledge of wind speeds and directions. We also evaluate the multi time-step reconstruction method and the wind estimation method on the RAVEN demonstrator under laboratory setting conditions. The wind speeds and directions at multiple atmospheric layers are measured successfully in the laboratory experiment by our wind estimation method with errors below 2 ms-1. With these wind estimates, the multi time-step reconstructor increases the SR value by a factor of 1.2-1.5, which is consistent with a prediction from the end-to-end numerical simulation.

Experimental study of combination of extraaortic balloon counterpulsation and ventricular assist cup to acute heart failure in dogs.

The goal of this study is to evaluate the applicability and effectiveness of combination support of the extraaortic balloon (EAB) and the ventricular assist cup (VAC) to the acute heart failure model. Under general anesthesia, 10 adult dogs were used. Through the median sternotomy, EAB was placed around the ascending aorta and VAC in the pericardial cavity. After heart failure was induced by administration of propranolol, the on-off tests of devices were done as follows. Only EAB was used, and only VAC was used and both devices were used. Regional blood flows (RBFs) of both ventricles, liver kidneys, and brain were measured by colored microsphere technique. Hemodynamic parameters were also measured. In heart failure model, cardiac output (CO) decreased to 66% of control value. In the group assisted by EAB, aortic peak-diastolic pressure and RBFs of both ventricle and brain increased significantly. In the group assisted by VAC, CO and RBFs of all but the left ventricle significantly increased. In the group assisted by EAB and VAC, aortic peak-diastolic pressure, CO, and all five RBFs significantly increased. These results suggest the combination of EAB and VAC is applicable and effective and would be a promising implantable device for the chronic heart failure.

A percutaneously accessible pulsatile left ventricular assist device: modified assist device type 5.

To provide percutaneous access, a new circulatory assist system was developed. We call this newly developed system the modified assist device (MAD). The system is composed of a sac-type blood pump and cannula. Inflow and outflow valves are mounted in the apex and at the side wall 10 cm from the apex of the cannula, respectively. During systole, the blood is sucked from the left ventricle through the inflow valve of the cannula connected to the blood pump, and during diastole, the blood is ejected to the root of the aorta through the outflow valve. In vitro and in vivo evaluations of the pump performance were performed. The maximum flow rate of 1.9 L/min was obtained in the mock circulatory system. In our animal experiment, effective systolic unloading and diastolic augmentation were observed by activation of this system during regular sinus rhythm. In conclusion, the MAD-5 is thought to be percutaneously accessible and increases systemic and coronary flow.