Evidence-based concepts for prevention of knee and ACL injuries. 2017 guidelines of the ligament committee of the German Knee Society (DKG).

INTRODUCTION: Knee injuries and especially anterior cruciate ligament (ACL) tears are frequent in athletes. Therefore, primary and secondary prevention of sports-related lower limb injuries is an ongoing topic of interest. The aim of present study was to establish guidelines for the prevention of knee and ACL injuries on the basis of evidence-based concepts represented in current literature. METHODS: A comprehensive literature review regarding prevention programs for knee and ACL injuries was conducted. RESULTS: Several modifiable and non-modifiable risk factors for knee injuries in athletes have been reported in literature. Referring to the ACL, specific injury mechanisms have been identified and are well understood. In particular, it has been demonstrated that dynamic valgus is one of the most important modifiable risk factors. Simple tests like the drop jump test have shown their efficacy in screening and detecting athletes at risk. There is only few evidence for the preventive effect on knee and ACL injuries by single exercises. However, in order to prevent or correct endangering movement patterns including dynamic valgus, several complex prevention programs have been developed in the past. These prevention programs are included in standard warm-up exercises and are focusing on muscle strength, balance, and proprioception, as well as running and flexibility. It is reported that these training programs can reduce the incidence of knee injuries by up to 27% and ACL injuries by up to 51%. CONCLUSIONS: Screening, identification, and correction of endangering movement patterns like the dynamic valgus are the first crucial steps in order to prevent knee and ACL injuries in athletes. Furthermore, jumping, running and flexibility exercises as well as balance and strength training are proven to reduce the incidence of these injuries and should, therefore, be integrated into the regular warm up program. Appropriate complete prevention programs are freely accessible via the Internet and should be adapted to the specific sport disciplines.

Effects of a novel foot-ankle orthosis in the non-operative treatment of unicompartmental knee osteoarthritis.

INTRODUCTION: Unloader braces are non-surgical treatment options for patients with unicompartmental knee osteoarthritis (OA). However, many patients do not adhere to brace treatment because of complications related to discomfort and poor fit. An alternative to knee bracing is an ankle-foot orthosis (AFO) with a lever arm that presses the lower leg into valgus or varus. The aim of this study is to evaluate the clinical benefits of this AFO for patients with unicompartmental knee OA. MATERIALS AND METHODS: Twenty-three patients with knee OA were enrolled in this observational study. The primary clinical outcome measure was the Western Ontario and McMasters Universities Arthritis Index (WOMAC) total score. Secondary outcome measures included WOMAC subscores, visual analogue pain scale, activity restriction and complication rate. Clinical scores were collected at start and 3, 6, 9, and 12 months after enrollment. Statistical evaluation was performed using the Student's t test. RESULTS: Of the patients enrolled, 83 % suffered from medial compartment OA. Most patients had Grade II OA according to the Kellgren and Lawrence classification. WOMAC total score, both subscores and visual analogue pain scale were significantly improved over time. Patients also noted a reduction in restrictions to activities of daily living and sport-related activities while using the AFO. No patients discontinued orthosis use because of adverse effects. Two types of complications were noted: discomfort or light pressure sores around the ankle (7 patients), and wear and tear of the shoe in which the AFO was worn (14 patients). CONCLUSIONS: This observational study suggests that this AFO is effective at significantly reducing pain and stiffness as well as improving the physical function of patients with mild to moderate unicompartmental osteoarthritis of the knee.

Conventional over-the-top-aiming devices with short offset fail to hit the center of the human femoral ACL footprint in medial portal technique, whereas medial-portal-aiming devices with larger offset hit the center reliably.

INTRODUCTION: Aim of this study was to investigate the accuracy of a conventional over-the-top-guide (OTG) with a typically short offset to hit the center of the native femoral ACL footprint through the anteromedial portal in comparison to a specific medial-portal-aimer (MPA) with larger offset. MATERIALS AND METHODS: In 20 matched human cadaveric knees, insertion sites of the ACL were marked in medial arthrotomy. An OTG with an offset of 5.5 mm, respectively, the MPA with 9 mm offset was used in a medial portal approach to locate the center of a single bundle ACL reconstruction tunnel with k-wires. Distances from the footprint center, the OTG drilling and the MPA drilling to the roof of the intercondylar notch and to the deep cartilage margin were determined. After positioning of radiological markers, radiographic analysis was performed according to the quadrant technique as described by Bernard and Hertel. RESULTS: The distance from ACL origin to the roof of the notch was 10.3 (±2.1) mm, in the OTG group 6.7 (±1.5) mm and in the MPA group 9.6 (±1.9) mm. The distance to the deep cartilage margin was 9.5 (±1.7) mm from ACL origin, 4.8 (±1.3) mm with OTG and 8.7 (±1.4) mm with MPA. There were statistically significant differences between the distances of the footprint center and the OTG group after measuring and also after radiographic analysis (p < 0.0001). Using the MPA, no significant different distances in comparison to the anatomical ACL center were found (p > 0.0001). There was an increased risk for femoral blow (9/10 vs. 0/10) in the OTG group after overdrilling with a 9 mm drill. CONCLUSION: Short (5.5 mm) offset femoral aiming devices fail to locate the native ACL footprint center in medial portal approach with an increased risk for femoral blowout when overdrilling. The special medial-portal-aiming device with 9 mm offset hit the center reliably.

Biomechanical effect of unloader braces for medial osteoarthritis of the knee: a systematic review (CRD 42015026136).

PURPOSE: There is a lack of consensus regarding biomechanical effects of unloader braces for the treatment of medial osteoarthritis (OA) of the knee. The purpose of this study was to perform a systematic review of studies examining the biomechanical effect of unloader braces. METHODS: A systematic search for articles about the biomechanical effect of unloader braces was performed. Primary outcome measure was the influence of the brace on the knee adduction moment. Data sources were Pubmed central and google scholar. RESULTS: Twenty-four articles were included. Twenty articles showed that valgus unloader braces significantly decrease the knee adduction moment. Seven of those studies reported a decrease of pain in braced patients (secondary outcome measure). Positive effects on the knee adduction moment could be found for custom made braces for conventional knee braces and for a foot ankle orthosis. Four studies could not show any effect of knee unloader braces on the knee adduction moment although one of these studies found decreased pain in braced patients. One of these studies examined healthy patients with a neutral axis. CONCLUSION: This systematic review could demonstrate evidence that unloader braces reduce the adduction moment of the knee. Foresighted, a systematic review about the clinical effect of unloader braces is required.

Evaluating the potential synergistic benefit of a realignment brace on patients receiving exercise therapy for patellofemoral pain syndrome: a randomized clinical trial.

BACKGROUND: It has been previously shown that exercise programs for patellofemoral pain syndrome (PFPS) can be supported by medially directed taping. Evidence supporting the use of patellar braces is limited because previous studies have been low quality. The aim of this study is to compare the outcomes of patients with PFPS after treatment with a medially directed patellar realignment brace and supervised exercise. METHODS: In a prospective randomized multicenter trial, 156 patients with PFPS were included and randomly assigned to 6 weeks of supervised physiotherapy in combination with the patellar realignment brace, or supervised physiotherapy alone. Outcome measures were the Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales, numeric analog pain scores, and the Kujala score at baseline, 6 weeks, 3 months, and 1 year after the start of therapy. The patient's self-reported perception of recovery was also assessed at these points. RESULTS: Both treatment groups showed a significant improvement in all outcome measures over the study period. After 6 and 12 weeks of therapy, patients in the brace group had significantly higher KOOS sub-scale scores, a higher mean Kujala score, and less pain while climbing stairs or playing sports. After 54 weeks a group difference could be only detected for the KOOS ADL sub-scale. CONCLUSION: The use of a medially directed realignment brace leads to better outcomes in patients with PFPS than exercise alone after 6 and 12 weeks of treatment. After 1 year of follow-up this positive effect diminished.

Midterm results following medial closed wedge distal femoral osteotomy stabilized with a locking internal fixation device.

PURPOSE: Aim of this study was to evaluate the subjective and radiological outcome and to evaluate the complications of a medial closing wedge osteotomy at the femur for lateral osteoarthritis with genu valgum. METHODS: Twenty-three patients with grade III to IV cartilage damage and valgus knee alignment were treated with medial closing wedge osteotomy at the distal femur. The osteotomy was stabilized with an internal plate fixator. Age varied between 25 and 55 years (mean 47 years). One patient was lost to final follow-up. RESULTS: After 3.5 years, all Knee Osteoarthritis Outcome Score (KOOS) subitems increased significantly. There was no significant difference in the subgroup analysis of KOOS subitems for patients with and without microfracture or age (>50 vs. <50 years). There were no perioperative complications. One patient had an overcorrection. All, but one osteotomy, showed stable bone healing. There was a loss of correction due to delayed bone healing in one case. Possible explanations for this complication were injury of the lateral cortex or smoking. This case required revision with bone graft and an additional lateral plate. In no case, a conversion to an endoprosthesis was necessary. CONCLUSION: The femoral medial closing wedge osteotomy is a surgical method for improving symptoms of lateral osteoarthritis in the valgus knee. LEVEL OF EVIDENCE: IV.

The effect of tibial slope in acute ACL-insufficient patients on concurrent meniscal tears.

INTRODUCTION: The aim of this study is to evaluate the effect of the medial and lateral posterior tibial slope (MPTS, LPTS) in patients with acutely ruptured ACL on the menisci. It was hypothesized that medial and lateral meniscus lesions are seen more often with high PTS (posterior tibial slope). We hypothesized that in case of a high tibial slope a possible meniscus lesion is more often located in the posterior horn of the meniscus than in knees with a low tibial slope. MATERIALS AND METHODS: We identified 537 patients with ACL insufficiency between 2012 and 2013. Of these, 71 patients were eligible for the study according to the study's criteria. PTS was measured via MRI and classified into two groups: >10° for high tibial slope and ≤10° for low tibial slope. Any meniscal lesion was documented during arthroscopic ACL reconstruction and evaluated regarding meniscal lesion patterns with high and low PTS, taking into account the type and the location of the tear (anterior horn, intermediate part and posterior horn). Statistical analysis for differences in meniscal lesion was performed using Chi-square tests and McNemar tests for dependent variables. The level of significance was set at p ≤ 0.05. RESULTS: High PTS (MPTS and LPTS) was associated with a higher incidence of meniscal lesions with an odds ratio of 2.11, respectively, 3.44; however, no statistical significance was found. Among the total number of ACL-insufficient knees studied, the meniscal lesion spread more often to the posterior part in the group with a low PTS. In contrast, less damage of the posterior horn of the meniscus could be found in the group with a high PTS. CONCLUSION: High PTS seems to predetermine for meniscal lesion in an acute ACL-insufficient knee. More damage to the posterior part of the menisci could generally be seen but was not associated with a high PTS. There was no statistical significance to support the initial hypothesis. Further research is needed to find out if factors other than tibial slope are risk factors for meniscal lesion in acute ACL injury. LEVEL OF EVIDENCE: IV.

Return to play following ACL reconstruction: a systematic review about strength deficits.

PURPOSE: There is a lack of consensus regarding appropriate criteria attesting patients' unrestricted sports activities after ACL reconstruction. Purpose of this study was to perform a systematic review about strength deficits to find out if a strength test might be a return to play criterion. DATA SOURCE: Pubmed central, Google Scholar. STUDY ELIGIBILITY CRITERIA: English language articles. INTERVENTIONS: Strength tests after ACL reconstruction with autologous tendon grafts. METHODS: A systematic search for articles about muscle strength after ACL reconstruction was performed. RESULTS: Forty-five articles could be identified. All articles identified reported strength deficits after ACL reconstruction in comparison to control subjects. Some of these deficits persisted up to 5 years after surgery. Knee flexor strength is more impaired after ACL reconstruction with hamstring grafts and quadriceps strength after BPTB ACL reconstruction. CONCLUSION: Strength deficits of hip, knee and ankle muscles are reported after ACL reconstruction. Muscular strength test may be an important tool to determine if an athlete can return to competitive sports after ACL reconstruction.

Degradation of poly-D-L-lactide (PDLLA) interference screws (Megafix ®).

INTRODUCTION: Interference screw fixation is a standard procedure in anterior cruciate ligament (ACL) replacement. Aim of this study was to evaluate the degradation process of Poly-D-L-lactide (PDLLA) interference screws used for tibial ACL graft fixation. MATERIALS AND METHODS: We evaluated magnetic resonance imaging (MRI) scans of 18 patients who underwent ACL revision surgery at different time points after anatomic ACL reconstruction. At primary surgery, a tibial hybrid fixation was performed with a degradable interference (IF) screw made of PDLLA (Megafix(®)) and a button. RESULTS: MRI revealed three different phases of degradation of the PDLLA screw. 6-8 months after surgery the IF screw was clearly visible as a well-defined structure on MRI and CT scan. After 12-16 months, the screws appeared less defined with central ingrowths' of connective tissue. In some cases only fragmented screw material was visible. At these time points, there was a slight edema surrounding the tunnel visible on MRI. After 22 months and later, the mean screw site densities were comparable with the surrounding bone density. There was no edema or signs of inflammation around the bone tunnels visible. Presence of cystic or osteolytic changes was not detected. CONCLUSION: After 22 months, a PDLLA screw may not interfere with ACL revision surgery. Regarding the degradation process of PDLLA screws, we noted three different phases. Furthermore, the degradation process observed by MRI resembles to that described by animal studies. The PDLLA screws fully absorb and are partially replaced by bone. The degradation process in humans seems to be longer than that described in animals.

Posterior root tear of the medial and lateral meniscus.

An avulsion of the tibial insertion of the meniscus or a radial tear close to the meniscal insertion is defined as a root tear. In clinical practice, the incidence of these lesions is often underestimated. However, several biomechanical studies have shown that the effect of a root tear is comparable to a total meniscectomy. Clinical studies documented progredient arthritic changes following root tears, thereby supporting basic science studies. The clinical diagnosis is limited by unspecific symptoms. In addition to the diagnostic arthroscopy, MRI is considered to be the gold standard of diagnosis of a meniscal root tear. Three different direct MRI signs for the diagnosis of a meniscus root tear have been described: Radial linear defect in the axial plane, vertical linear defect (truncation sign) in the coronal plane, and the so-called ghost meniscus sign in the sagittal plane. Meniscal extrusion is also considered to be an indirect sign of a root tear, but is less common in lateral root tears. During arthroscopy, the function of the meniscus root must be assessed by probing. However, visualization of the meniscal insertions is challenging. Refixation of the meniscal root can be performed using a transtibial pull-out suture, suture anchors, or side-to-side repair. Several short-term studies reported good clinical results after medial or lateral root repair. Nevertheless, MRI and second-look arthroscopy revealed high rates of incomplete or absent healing, especially for medial root tears. To date, most studies are case series with short-term follow-up and level IV evidence. Outerbridge grade 3 or 4 chondral lesions and varus malalignment of >5° were found to predict an inferior clinical outcome after medial meniscus root repair. Further research is needed to evaluate long-term results and to define evident criteria for meniscal root repair.

Single-bundle anterior cruciate ligament reconstruction: a biomechanical cadaveric study of a rectangular quadriceps and bone--patellar tendon--bone graft configuration versus a round hamstring graft.

PURPOSE: The purposes of this study were to investigate anterior tibial translation under loading conditions after single-bundle (SB) anterior cruciate ligament (ACL) reconstruction using a rectangular tunnel placement strategy with quadriceps and bone--patellar tendon--bone (BPTB) graft and to compare these data with a SB hamstring reconstruction with a round tunnel design. METHODS: In 9 human cadaveric knees, the knee kinematics were examined with robotic/universal force-moment sensor testing. Within the same specimen, the knee kinematics under simulated pivot-shift and KT-1000 arthrometer (MEDmetric, San Diego, CA) testing were determined at 0°, 15°, 30°, 60°, and 90° of flexion under different conditions: intact knee, ACL-deficient knee, and SB ACL-reconstructed knee. For the SB ACL-reconstructed knee, 3 different SB reconstruction techniques were used: a rectangular tunnel strategy (9 × 5 mm) with quadriceps graft, a rectangular tunnel strategy with BPTB graft, and a round tunnel strategy (7 mm) with hamstring graft. RESULTS: In a simulated Lachman test, a statistically significant difference was found at 0° and 15° of knee flexion between the rectangular reconstruction with quadriceps graft (5.1 ± 1.2 mm and 8.3 ± 2 mm, respectively) or BPTB graft (5.3 ± 1.5 mm and 8 ± 1.9 mm, respectively) and the reconstruction using hamstring graft (7.2 ± 1.4 mm and 12 ± 1.8 mm, respectively) (P = .032 and P = .033, respectively, at 0°; P = .023 and P = .02, respectively, at 15°). On the simulated pivot-shift test at 0° and 15°, rectangular ACL reconstruction with quadriceps graft (3.9 ± 2.1 mm and 6.5 ± 1.7 mm, respectively) or BPTB graft (4.2 ± 1.8 mm and 6.7 ± 1.7 mm, respectively) showed a significantly lower anterior tibial translation when compared with round tunnel reconstruction (5.5 ± 2.1 mm and 7.9 ± 1.9 mm, respectively) (P = .03 and P = .041, respectively, at 0°; P = .042 and P = .046, respectively, at 15°). CONCLUSIONS: Under simulated Lachman testing and pivot-shift testing, a reconstruction technique using a rectangular tunnel results in significantly lower anterior tibial translation at 0° and 15° of flexion in comparison to knees reconstructed with a hamstring SB graft using a round tunnel strategy. CLINICAL RELEVANCE: ACL reconstruction with a rectangular tunnel and BPTB and quadriceps tendon might result in better anterior knee stability at low flexion angles than ACL reconstruction with hamstring SB graft and a round tunnel in the clinical setting.

Anteroposterior and rotational stability in fixed and mobile bearing unicondylar knee arthroplasty: a cadaveric study using the robotic force sensor system.

PURPOSE: Different bearing designs in unicondylar knee arthroplasty (UKA) have been developed in order to influence the rate of polyethylene wear. Increased anteroposterior translation and rotation after UKA has been hypothesized due to changes in joint surface geometry. The mobile bearing design was expected to show increased anteroposterior translation compared to the fixed bearing and biconcave bearing design. METHODS: Six human cadaver knees were used for the tests. Anteroposterior and rotational knee stability was analysed in 0°, 30°, 60°, 90° and 120° of knee flexion using a robotic testing system (KR 125, KUKA Robots Augsburg, Germany). Three forces and moments were measured in a Cartesian coordinate system with a resolution of 1.0 N and 0.1 Nm. RESULTS: There was no difference between the native knees and the knees after UKA in AP translation and rotation in all knee flexion angles. The factor knee flexion angle had a significant impact on the anterior translation when the type of bearing was neglected (p ≤ 0.015). CONCLUSION: This study shows that the natural knee stability in AP translation and rotation can be preserved in UKA. The preserved knee stability in different planes after UKA underlines the advantage of UKA when surgery is required in osteoarthritic changes of the medial compartment.

Return to play following ACL reconstruction: survey among experienced arthroscopic surgeons (AGA instructors).

PURPOSE: There is a lack of consensus regarding appropriate criteria attesting patient's unrestricted sports activities after ACL reconstruction. The purpose of this study was to perform a survey among experienced arthroscopic surgeons regarding their return to play guidelines in these patients. METHODS: A six-item questionnaire was distributed among experienced arthroscopic surgeons (instructors of the German speaking society of arthroscopy, AGA). Study participants were asked to choose from multiple choice answers and had the possibility answering in an open discussion field. RESULTS: The response rate of the survey was 85.7 %. A total of 83.5 % used autologous hamstring grafts for ACL reconstruction in athletes followed by BPTB (37.2 %) and quadriceps tendon graft (12 %). Approximately 63.5 % recommended a time point later than 6 months allowing return to play after ACL reconstruction in the athlete (after 4 and 6 months 2.3 and 35.3 %, respectively). 76.6 % recommended starting with sports specific rehabilitation after 4 months (21.6 % after 6 months). The most frequent criterion (multiple answers) to allow return to play was negative Lachman test (81.7 % positive answers) followed by free range of motion (78.4 %), negative pivot shift (60.1 %), anterior drawer (45.4 %), proprioception test (43.1 %), muscular strength analysis (40.8 %), single-leg hop jump test (39.0 %), KT 1000 measurement (16.1 %), and MRI (4.1 %). Of the surgeons 85.8 % did not use any of the given scores as criterion to allow return to competitive sports (subjective IKDC score 10.6 %, Lysholm score 8.3 %, objective IKDC score 7.4 %, Tegner activity scale 3.7 %). CONCLUSION: In conclusion, the majority of surgeons do not consider muscle function, jump tests, alignment tests, and proprioception as relevant return to sports criterion. However, these are two crucial parameters for return to sports.

Technique of anatomical footprint reconstruction of the ACL with oval tunnels and medial portal aimers.

PURPOSE: The purpose of this article was to demonstrate an anterior cruciate ligament (ACL) reconstruction technique using oval tunnels. Aim of this single bundle technique is to fit the footprint anatomy of the ACL as closely as possible. TECHNIQUE AND PATIENTS: The presented technique is a single bundle technique using a semitendinosus graft. For femoral tunnel placement, a specific medial portal aimer (Karl Storz, Tuttlingen, Germany) is used. Aiming and drilling of the femoral tunnel are performed via the medial portal. Oval tunnels are created by stepwise dilatation with ovally shaped dilatators. The position of the femoral tunnel is visualized and controlled with the arthroscope via the medial portal. For the tibial tunnel placement, a specific aimer was used as well. With this technique, 24 patients were operated and all intra- and postoperative complications were analyzed prospectively. The tunnel position was documented postoperatively by CT scan. RESULTS: There were no significant intra- and postoperative complications associated with the oval tunnel technique. The postoperative 3D CT scan revealed that all femoral and tibial tunnels were located within the area of the anatomical ACL insertions. CONCLUSIONS: This article presents an ACL reconstruction technique using oval dilatators and medial portal aimers to create oval tunnels. These oval tunnels match the insertion site anatomy much closer than round tunnels do. LEVEL OF EVIDENCE: Level IV, case series.

Mincing bovine articular cartilage with commercially available shavers reduces the viability of chondrocytes compared to scalpel mincing.

PURPOSE: The study aimed to compare the effect of mincing bovine articular cartilage with different shaver blades on chondrocyte viability. METHODS: Bovine articular cartilage was harvested either with a scalpel or with three different shaver blades (2.5 mm, 3.5 mm, or 4.2 mm) from a commercially available shaver. The cartilage harvested with a scalpel was then minced into fragments smaller than 1 mm3 with a scalpel. All four conditions were cultivated in a culture medium for seven days. After Day 1 and Day 7, the following measurements were performed: metabolic activity, RNA isolation, and gene expression of anabolic (COL2A1 and ACAN) and catabolic genes (MMP1 and MMP13), live/dead staining and visualization using confocal microscopy, and flow cytometric characterization of minced cartilage chondrocytes. RESULTS: Mincing the cartilage with shavers significantly reduced metabolic activity after one and seven days compared to scalpel mincing (p < 0.001). Gene expression of anabolic genes (COL2A1 and ACAN) was reduced, while catabolic genes (MMP1 and MMP13) were increased after day 7 in all shaver conditions. Confocal microscopy showed a thin line of dead cells at the lesion side with viable cells beneath for the scalpel mincing and a higher number of dead cells diffusely distributed in the shaver conditions. After seven days, there was a significant decrease in viable cells in the shaver conditions compared to scalpel mincing (p < 0.05). Flow cytometric characterization revealed fewer intact cells and proportionally more dead cells in all shaver conditions compared to the scalpel mincing. CONCLUSION: Mincing bovine articular cartilage with commercially available shavers reduces the viability of chondrocytes compared to scalpel mincing immediately after harvest and after seven days in culture. This suggests that mincing cartilage with a shaver should be considered a matrix rather than a cell therapy. LEVEL OF EVIDENCE: Level II therapeutic study.

Reconstruction of the posterior oblique ligament and the posterior cruciate ligament in knees with posteromedial instability.

PURPOSE: Posterior cruciate ligament (PCL) injuries are often associated with injuries of the posteromedial structures of the knee. The motivation for this study was the attempt to test different reconstruction techniques for the structures of the posteromedial corner in a biomechanical experiment. METHODS: Kinematic studies were carried out on 10 cadaveric knees exposed to a 134-N posterior tibial load, 10-Nm valgus torque, and 5-Nm internal torque at 0°, 30°, 60°, and 90° of flexion. The resulting posterior tibial translation (PTT) was determined using a robotic/universal force-moment sensor testing system for (1) intact knees, (2) PCL-deficient knees, (3) knees with deficiency of the PCL and the posteromedial structures, (4) knees with only the PCL reconstructed, (5) knees with the PCL and posterior oblique ligament (POL) reconstructed, and (6) knees with the PCL, medial collateral ligament (MCL), and POL reconstructed. Kinematic data were analyzed by a 2-factor repeated analysis of variance. RESULTS: When both the PCL and the posteromedial structures were cut, PTT increased significantly at all flexion grades under a posterior tibial load (P < .05). Reconstruction of only the PCL could not restore PTT at 0°, 30°, 60°, and 90° of flexion under loading conditions in a knee with combined injury of the PCL and the posteromedial structures (P > .05). Additional reconstruction of the POL improved PTT at all flexion angles in comparison with only the PCL-reconstructed knee. Reconstruction of the MCL had no significant effect on PTT. CONCLUSIONS: This study shows that reconstruction of the POL contributes significantly to the normalization of coupled PTT in knees with combined injury of the PCL and the posteromedial structures under valgus or internal rotational moment. The supplementary reconstruction of the MCL did not provide significant improvement in knee kinematics. CLINICAL RELEVANCE: The POL should be addressed in the patient with combined injuries of the PCL and the posteromedial structures.

Accidental perforation of the lateral femoral cortex in ACL reconstruction: an investigation of mechanical properties of different fixation techniques.

PURPOSE: The aim of this study was to evaluate the mechanical properties of anterior cruciate ligament (ACL) reconstruction using the medial portal technique with cortical fixation and hybrid fixation after penetration of the lateral cortex by use of different drill sizes. METHODS: In this biomechanical study a porcine in vitro model was used. The testing protocol consisted of a cyclic loading protocol (1,000 cycles, 50 and 250 N) and subsequent ultimate failure testing. Number of cyclic loadings survived, stiffness, yield load, maximum load, and graft elongation, as well as failure mode, were analyzed after ACL reconstruction with 5- to 9-mm soft-tissue grafts. In the control group, conventional penetration of the lateral cortex with a 4.5-mm drill and cortical fixation were performed. In the tested groups, the lateral cortex was penetrated with a drill matching the graft size. In the first part of the study, we used cortical fixation. In the second part, we used hybrid fixation with an interference screw. RESULTS: In the first part of the study, ACL reconstruction with 5- to 6-mm perforation of the lateral cortex showed no significant differences in ultimate failure load after cyclic loading compared with the control group (P > .05). Specimens with reconstruction with 7- to 9-mm perforation of the lateral cortex and cortical fixation did not survive the cyclic loading protocol. In the second part of the study, with a hybrid fixation technique, ultimate failure testing after cyclic loading of specimens with 7- to 9-mm penetration showed no significant differences in tested parameters compared with the control group (P > .05). CONCLUSIONS: After penetration of the lateral cortex with a drill size of more than 6 mm, cortical ACL fixation results in poor mechanical properties. Hybrid fixation increases the mechanical properties significantly after penetration with a 7- to 9-mm drill. CLINICAL RELEVANCE: We advise caution to avoid penetration of the lateral femoral cortex when using cortical flip-button fixation. In case of accidental perforation of the lateral cortex with a diameter greater than 6 mm, we recommend performing hybrid fixation.

Arthroscopic fixation of matrix-associated autologous chondrocyte implantation: importance of fixation pin angle on joint compression forces.

PURPOSE: The aim of the study was to investigate the effect of pin fixation perpendicular and 30° tilted to the matrix surface on the joint compression forces. METHODS: In a porcine knee model, joint compression forces were recorded with a digital pressure sensor above the medial meniscus and with axial compression of 100 N by use of a material testing machine. The forces were recorded for an intact femoral condyle, as well as a standardized cartilage defect of 25 × 20 mm, after matrix-associated autologous chondrocyte implantation (m-ACI) (BioSeed C; Biotissue Technologies, Freiburg, Germany), fixed by use of a conventional suture technique and pin fixation with a biodegradable pin perpendicular and 30° tilted to the matrix surface. RESULTS: In knees with cartilage defects, the peak compression forces (mean, 824 kPa) were significantly increased compared with the intact knee joint (564 kPa). After m-ACI implantation with a chondral suture (581.3 kPa) and perpendicular pin fixation, the joint compression forces of the cartilage defect were significantly decreased (630.7 kPa). There were no significant differences compared with the intact knee. After 30° tilted pin insertion, mean joint compression forces were significantly increased (1,740 kPa). CONCLUSIONS: This study shows that after chondral suture and perpendicular pin fixation, there are no increased compression forces in the knee joint in comparison to an intact knee. Thirty degree tilted pin insertion contributes to increased joint compression forces. CLINICAL RELEVANCE: A tilted insertion during pin fixation in m-ACI should be avoided because it may lead to increased joint compression forces, especially after cartilage defect lesions on the tibial side.

ACL mismatch reconstructions: influence of different tunnel placement strategies in single-bundle ACL reconstructions on the knee kinematics.

To evaluate the influence of tibial and femoral tunnel position in ACL reconstruction on knee kinematics, we compared ACL reconstruction with a tibial and femoral tunnel in anteromedial (AM-AM reconstruction) and in posterolateral footprint (PL-PL reconstruction) with a reconstruction technique with tibial posterolateral and femoral anteromedial tunnel placement (PL-AM reconstruction). In 9 fresh-frozen human cadaveric knees, the knee kinematics under simulated Lachman (134 N anterior tibial load) and a simulated pivot shift test (10 N/m valgus and 4 N/m internal tibial torque) were determined at 0°, 30°, 60°, and 90° of flexion. Kinematics were recorded for intact, ACL-deficient, and single-bundle ACL reconstructed knees using three different reconstruction strategies in randomized order: (1) PL-AM, (2) AM-AM and (3) PL-PL reconstructions. Under simulated Lachman test, single-bundle PL-AM reconstruction and PL-PL reconstructions both showed significantly increased anterior tibial translation (ATT) at 60° and 90° when compared to the intact knee. At all flexion angles, AM-AM reconstruction did not show any statistical significant differences in ATT compared to the intact knee. Under simulated pivot shift, PL-AM reconstruction resulted in significantly higher ATT at 0°, 30°, and 60° knee flexion and AM-AM reconstructions showed significantly higher ATT at 30° compared to the intact knee. PL-PL reconstructions did not show any significant differences to the intact knee. AM-AM reconstructions restore the intact knee kinematics more closely when compared to a PL-AM technique resembling a transtibial approach. PL-PL reconstructions showed increased ATT at higher flexion angles, however, secured the rotational stability at all flexion angles. Due to the independent tibial and femoral tunnel location, a medial portal technique may be superior to a transtibial approach.

Double-bundle reconstruction cannot restore intact knee kinematics in the ACL/LCL-deficient knee.

INTRODUCTION: The aim of this study was to evaluate the effect of single-bundle (SB) and anatomic double-bundle (DB) anterior cruciate ligament (ACL) reconstruction on the resulting knee kinematics in a simulated clinical setting with ACL rupture and associated extra-articular damage to the lateral structures. It was hypothesized that anatomic DB ACL reconstruction restores the intact knee kinematics in ACL/LCL-deficient knees, whereas SB ACL reconstruction fails to restore the intact knee kinematics. MATERIALS AND METHODS: Ten fresh-frozen human cadaver knees were subjected to anterior tibial load of 134 N (simulated KT 1000) and combined rotatory load of 10-Nm valgus and 4-Nm internal tibial torque (simulated pivot shift) using a robotic/UFS testing system. The resulting knee kinematics was determined for intact, ACL/LCL-deficient, SB ACL-reconstructed/LCL-deficient, and DB ACL-reconstructed/LCL-deficient knee. Statistical analysis was performed using a two-way ANOVA test with the level of significance set at P < 0.05. RESULTS: Under a simulated KT 1000 test, anterior tibial translation (ATT) following SB ACL reconstruction was statistically significant at 0 degrees , 30 degrees and 60 degrees of knee flexion when compared to the intact knee. ATT after DB ACL reconstruction showed no statistically significant difference from the intact knee; however, there was a significant difference in SB reconstruction at 0 degrees and 30 degrees of knee flexion. Under a simulated pivot shift test, both SB and DB ACL reconstruction failed to restore the intact knee kinematics. CONCLUSION: The results of the study did not support our initial hypothesis. Though DB reconstructions were significantly superior to SB reconstruction under simulated KT 1000 test, SB as well as DB reconstruction failed to restore the intact kinematics under simulated pivot shift loads. The clinical relevance of this study is that caution and precise preoperative diagnostics are needed to avoid failure of intra-articular ACL reconstruction if the extra-articular stabilizers are torn.