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1.
Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Cell
; 181(3): 688-701.e16, 2020 04 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32315618
2.
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
Proc Natl Acad Sci U S A
; 119(14): e2117112119, 2022 04 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35344430
3.
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Bioorg Med Chem Lett
; 27(7): 1602-1607, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28258797
4.
Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.
Bioorg Med Chem Lett
; 27(15): 3423-3430, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28610978
5.
Reengineered tricyclic anti-cancer agents.
Bioorg Med Chem
; 23(19): 6528-34, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26372073
6.
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Bioorg Med Chem
; 21(4): 891-902, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23332369
7.
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Bioorg Med Chem
; 21(7): 1857-64, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23434139
8.
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively.
bioRxiv
; 2023 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36711980
9.
N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Bioorg Med Chem
; 20(7): 2444-54, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22370340
10.
Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry.
Molecules
; 16(5): 3648-62, 2011 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-21540794
11.
Corrigendum to "Reengineered tricyclic anti-cancer agents" [Bioorg. Med. Chem. 23 (2015) 6528-6534].
Bioorg Med Chem
; 23(23): 7487, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28290285
12.
Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma.
Brain Commun
; 2(1): fcaa002, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32954276
13.
Bromodomain biology and drug discovery.
Nat Struct Mol Biol
; 26(10): 870-879, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31582847
14.
Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer.
Cancer Res
; 78(8): 2065-2080, 2018 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29358171
15.
Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells US2015011543 (a1): a patent evaluation.
Expert Opin Ther Pat
; 27(11): 1177-1181, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28753410
16.
Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation.
Curr Opin Chem Biol
; 39: 116-125, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28689146
17.
AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.
Cancer Lett
; 388: 149-157, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27939695
18.
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.
J Clin Invest
; 127(6): 2081-2090, 2017 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28504649
19.
Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
ACS Med Chem Lett
; 4(12): 1148-1151, 2013 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24470841
20.
Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
J Med Chem
; 53(4): 1563-78, 2010 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20092323
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