Búsqueda | Biblioteca Virtual en Salud Fronteriza

1.

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.

Liang, Yi-Lynn; Belousoff, Matthew J; Zhao, Peishen; Koole, Cassandra; Fletcher, Madeleine M; Truong, Tin T; Julita, Villy; Christopoulos, George; Xu, H Eric; Zhang, Yan; Khoshouei, Maryam; Christopoulos, Arthur; Danev, Radostin; Sexton, Patrick M; Wootten, Denise.

Mol Cell ; 77(3): 656-668.e5, 2020 02 06.

Artículo en Inglés | MEDLINE | ID: mdl-32004469

2.

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

Zhang, Xin; Belousoff, Matthew J; Zhao, Peishen; Kooistra, Albert J; Truong, Tin T; Ang, Sheng Yu; Underwood, Christina Rye; Egebjerg, Thomas; Senel, Petr; Stewart, Gregory D; Liang, Yi-Lynn; Glukhova, Alisa; Venugopal, Hari; Christopoulos, Arthur; Furness, Sebastian G B; Miller, Laurence J; Reedtz-Runge, Steffen; Langmead, Christopher J; Gloriam, David E; Danev, Radostin; Sexton, Patrick M; Wootten, Denise.

Mol Cell ; 80(3): 485-500.e7, 2020 11 05.

Artículo en Inglés | MEDLINE | ID: mdl-33027691

3.

Activation of the GLP-1 receptor by a non-peptidic agonist.

Zhao, Peishen; Liang, Yi-Lynn; Belousoff, Matthew J; Deganutti, Giuseppe; Fletcher, Madeleine M; Willard, Francis S; Bell, Michael G; Christe, Michael E; Sloop, Kyle W; Inoue, Asuka; Truong, Tin T; Clydesdale, Lachlan; Furness, Sebastian G B; Christopoulos, Arthur; Wang, Ming-Wei; Miller, Laurence J; Reynolds, Christopher A; Danev, Radostin; Sexton, Patrick M; Wootten, Denise.

Nature ; 577(7790): 432-436, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31915381

4.

Structural and functional diversity among agonist-bound states of the GLP-1 receptor.

Cary, Brian P; Deganutti, Giuseppe; Zhao, Peishen; Truong, Tin T; Piper, Sarah J; Liu, Xinyu; Belousoff, Matthew J; Danev, Radostin; Sexton, Patrick M; Wootten, Denise; Gellman, Samuel H.

Nat Chem Biol ; 18(3): 256-263, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-34937906

5.

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

Liang, Yi-Lynn; Khoshouei, Maryam; Glukhova, Alisa; Furness, Sebastian G B; Zhao, Peishen; Clydesdale, Lachlan; Koole, Cassandra; Truong, Tin T; Thal, David M; Lei, Saifei; Radjainia, Mazdak; Danev, Radostin; Baumeister, Wolfgang; Wang, Ming-Wei; Miller, Laurence J; Christopoulos, Arthur; Sexton, Patrick M; Wootten, Denise.

Nature ; 555(7694): 121-125, 2018 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-29466332

6.

Glycosylation Improves the Proteolytic Stability of Exenatide.

Chandrashekar, Chaitra; Nishiuchi, Yuji; White, Barbara Fam; Arsenakis, Yanni; Lin, Feng; McNeill, Samantha M; Zhao, Peishen; van Dun, Sam; Koijen, Anna; Kajihara, Yasuhiro; Wootten, Denise; van den Bos, Leendert J; Wade, John D; Hossain, Mohammed Akhter.

Bioconjug Chem ; 34(6): 1014-1018, 2023 06 21.

Artículo en Inglés | MEDLINE | ID: mdl-37192432

7.

Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors.

Lu, Jessica; Piper, Sarah J; Zhao, Peishen; Miller, Laurence J; Wootten, Denise; Sexton, Patrick M.

Int J Mol Sci ; 23(15)2022 Jul 22.

Artículo en Inglés | MEDLINE | ID: mdl-35897648

8.

AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists.

Fletcher, Madeleine M; Keov, Peter; Truong, Tin T; Mennen, Grace; Hick, Caroline A; Zhao, Peishen; Furness, Sebastian G B; Kruse, Thomas; Clausen, Trine R; Wootten, Denise; Sexton, Patrick M.

J Pharmacol Exp Ther ; 377(3): 417-440, 2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-33727283

9.

Chemical Synthesis and Characterization of a Nonfibrillating Glycoglucagon.

Liu, Mengjie; Zhao, Peishen; Uddin, Md Hemayet; Li, Wenyi; Lin, Feng; Chandrashekar, Chaitra; Nishiuchi, Yuji; Kajihara, Yasuhiro; Forbes, Briony E; Wootten, Denise; Wade, John D; Hossain, Mohammed Akhter.

Bioconjug Chem ; 32(10): 2148-2153, 2021 10 20.

Artículo en Inglés | MEDLINE | ID: mdl-34494823

10.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas, Nestor N; Pattison, Luke A; Zhao, Peishen; Lieu, TinaMarie; Latorre, Rocco; Jensen, Dane D; Castro, Joel; Aurelio, Luigi; Le, Giang T; Flynn, Bernard; Herenbrink, Carmen Klein; Yeatman, Holly R; Edgington-Mitchell, Laura; Porter, Christopher J H; Halls, Michelle L; Canals, Meritxell; Veldhuis, Nicholas A; Poole, Daniel P; McLean, Peter; Hicks, Gareth A; Scheff, Nicole; Chen, Elyssa; Bhattacharya, Aditi; Schmidt, Brian L; Brierley, Stuart M; Vanner, Stephen J; Bunnett, Nigel W.

Proc Natl Acad Sci U S A ; 115(31): E7438-E7447, 2018 07 31.

Artículo en Inglés | MEDLINE | ID: mdl-30012612

11.

Protein kinase D and GßÎ³ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.

Zhao, Peishen; Pattison, Luke A; Jensen, Dane D; Jimenez-Vargas, Nestor N; Latorre, Rocco; Lieu, TinaMarie; Jaramillo, Josue O; Lopez-Lopez, Cintya; Poole, Daniel P; Vanner, Stephen J; Schmidt, Brian L; Bunnett, Nigel W.

J Biol Chem ; 294(27): 10649-10662, 2019 07 05.

Artículo en Inglés | MEDLINE | ID: mdl-31142616

12.

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.

Lei, Saifei; Clydesdale, Lachlan; Dai, Antao; Cai, Xiaoqing; Feng, Yang; Yang, Dehua; Liang, Yi-Lynn; Koole, Cassandra; Zhao, Peishen; Coudrat, Thomas; Christopoulos, Arthur; Wang, Ming-Wei; Wootten, Denise; Sexton, Patrick M.

J Biol Chem ; 293(24): 9370-9387, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29717000

13.

Protein Kinase D and GßÎ³ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.

Jensen, Dane D; Zhao, Peishen; Jimenez-Vargas, Nestor N; Lieu, TinaMarie; Gerges, Marina; Yeatman, Holly R; Canals, Meritxell; Vanner, Stephen J; Poole, Daniel P; Bunnett, Nigel W.

J Biol Chem ; 291(21): 11285-99, 2016 May 20.

Artículo en Inglés | MEDLINE | ID: mdl-27030010

14.

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.

Zhao, Peishen; Lieu, TinaMarie; Barlow, Nicholas; Sostegni, Silvia; Haerteis, Silke; Korbmacher, Christoph; Liedtke, Wolfgang; Jimenez-Vargas, Nestor N; Vanner, Stephen J; Bunnett, Nigel W.

J Biol Chem ; 290(22): 13875-87, 2015 May 29.

Artículo en Inglés | MEDLINE | ID: mdl-25878251

15.

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

Zhao, Peishen; Lieu, TinaMarie; Barlow, Nicholas; Metcalf, Matthew; Veldhuis, Nicholas A; Jensen, Dane D; Kocan, Martina; Sostegni, Silvia; Haerteis, Silke; Baraznenok, Vera; Henderson, Ian; Lindström, Erik; Guerrero-Alba, Raquel; Valdez-Morales, Eduardo E; Liedtke, Wolfgang; McIntyre, Peter; Vanner, Stephen J; Korbmacher, Christoph; Bunnett, Nigel W.

J Biol Chem ; 289(39): 27215-27234, 2014 Sep 26.

Artículo en Inglés | MEDLINE | ID: mdl-25118282

16.

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

Lieu, TinaMarie; Jayaweera, Gihan; Zhao, Peishen; Poole, Daniel P; Jensen, Dane; Grace, Megan; McIntyre, Peter; Bron, Romke; Wilson, Yvette M; Krappitz, Matteus; Haerteis, Silke; Korbmacher, Christoph; Steinhoff, Martin S; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Corvera, Carlos U; Bunnett, Nigel W.

Gastroenterology ; 147(6): 1417-28, 2014 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-25194674

17.

Regulation of RGS5 GAP activity by GPSM3.

Zhao, Peishen; Chidiac, Peter.

Mol Cell Biochem ; 405(1-2): 33-40, 2015 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-25842189

18.

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons.

Zhao, Peishen; Canals, Meritxell; Murphy, Jane E; Klingler, Diana; Eriksson, Emily M; Pelayo, Juan-Carlos; Hardt, Markus; Bunnett, Nigel W; Poole, Daniel P.

J Biol Chem ; 288(36): 25689-25700, 2013 Sep 06.

Artículo en Inglés | MEDLINE | ID: mdl-23913690

19.

The involvement of the Wnt/ß-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin.

Somanader, Deidree V N; Zhao, Peishen; Widdop, Robert E; Samuel, Chrishan S.

Biochem Pharmacol ; 223: 116130, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38490518

20.

The role of G protein-coupled receptor kinases in GLP-1R ß-arrestin recruitment and internalisation.

McNeill, Samantha M; Lu, Jessica; Marion C Carino, Carlo; Inoue, Asuka; Zhao, Peishen; Sexton, Patrick M; Wootten, Denise.

Biochem Pharmacol ; 222: 116119, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38461904

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