[The influence of depression on the aggregate state of blood in elderly patients with cardiovascular diseases].

The work is dedicated to the effects of the psychoemotional status of patients older than 65 suffering from coronary artery disease (CAD) and arterial hypertension (AH) on the aggregative status of blood. Sixty-eight patients with mild stable stenocardia accompanied by AH and comorbid depression (CD) were examined; 28 elderly patients with CAD, AH, and no CD constituted the comparison group. The study found that CD in elderly patients with stable stenocardia did not only lower the quality of life, but also worsened hemodynamic parameters. CD increases hypercoagulatory shift, inhibits the fibrinolytic system of blood, and elevates the risk of thrombus formation.

[Development of microencapsulating measles live vaccine]. / Razrabotka mikrokapsulirovannoi formy zhivoi korevoi vaktsiny.

Designing of non-injection methods of immunization against measles has recently turned into a topical issue. Development of mucosal vaccines ensuring the "entry gate" immunity, which is highly effective in airborne infection, is in the focus of attention. The authors developed a method of microencapsulating the viral particles into the matrix of pH-dependent polymers. Microencapsulated live measles vaccine shaped as 0.6-2.0 microm particles was obtained. The specific activity of measles virus in the drug was 3.36-4.31 log TCD50/0.5 ml. In subcutaneous immunization of guinea pigs with capsules, the best results were obtained in a single administration of vaccine based on ethylcrylate, sodium alginate/ chitosan and sodium slaginate/HMDA. In the intranasal administration of vaccine based on sodium alginate/spermin and sodium alginate/HMDA, there was a need in 2 and 3 stages of immunization.

[Elaboration of live measles vaccine technology on human embryo lung diploid cell culture L-68]. / Razrabotka tekhnologii proizvodstva zhivoi korevoi vaktsiny na osnove kul'tury kletok émbriona cheloveka L-68.

Measles predominates among childhood droplet infections in many countries. Immunization of all human beings sensitive to this infection is the only radical measure in controlling measles. The quality of a vaccine is primarily determined by the properties of the virus strains and cell cultures and technology of production. Now live measles vaccine is produced in or country on the basis of fibroblasts from Japanese quail embryo. The production of live measles vaccine in the primary cell cultures has a number of drawbacks caused by the nonstandard pattern of the substrate and the probability of contamination. The use the certified human diploid cells deposited in liquid nitrogen in sufficient quantities is promising. The authors have elaborated a new technology of live measles vaccine production by using the Leningrad-16 virus strain on the basis of attested L-68 diploid cell culture from the human fetal lung. Experimental batches of vaccine were obtained and attested in accordance with the present requirements for immunobiological products.