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1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26046436
2.
Identification of WB4101, an α1-Adrenoceptor Antagonist, as a Sodium Channel Blocker.
Mol Pharmacol
; 94(2): 896-906, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29884692
3.
Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.
Acta Pharmacol Sin
; 37(1): 111-23, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26725739
4.
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.
Proc Natl Acad Sci U S A
; 110(21): 8732-7, 2013 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-23650380
5.
Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.
Mol Pharmacol
; 87(2): 207-17, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25422141
6.
Ion channel profiling to advance drug discovery and development.
Drug Discov Today Technol
; 18: 18-23, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26723888
7.
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.
Proc Natl Acad Sci U S A
; 109(29): 11866-71, 2012 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-22745159
8.
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.
Bioorg Med Chem Lett
; 24(16): 3968-73, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25017033
9.
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
J Biol Chem
; 287(47): 39613-25, 2012 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-23033485
10.
MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site.
Biochem J
; 414(1): 63-71, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18419581
11.
Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia.
Neuropharmacology
; 117: 282-291, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28216001
12.
Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila.
J Neurosci
; 24(1): 282-5, 2004 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-14715960
13.
Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels.
Br J Pharmacol
; 172(13): 3370-82, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25752739
14.
Global analysis reveals families of chemical motifs enriched for HERG inhibitors.
PLoS One
; 10(2): e0118324, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25700001
15.
Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel.
Eur J Pharmacol
; 740: 603-10, 2014 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-24972239
16.
Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor.
J Med Chem
; 55(15): 6975-9, 2012 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22793372
17.
hERGCentral: a large database to store, retrieve, and analyze compound-human Ether-à-go-go related gene channel interactions to facilitate cardiotoxicity assessment in drug development.
Assay Drug Dev Technol
; 9(6): 580-8, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22149888
18.
Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.
ACS Chem Neurosci
; 2(10): 572-577, 2011 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-22125664
19.
Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.
Assay Drug Dev Technol
; 8(6): 743-54, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21158688
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