Within and beyond the visual cortex: brain tumors induce highly sensitive plasticity of visual processing in whole-brain neural functional networks.

Vision is a key source of information input for humans, which involves various cognitive functions and a great range of neural networks inside and beyond the visual cortex. There has been increasing observation that the cognitive outcomes after a brain lesion cannot be well predicted by the attributes of the lesion itself but are influenced by the functional network plasticity. However, the mechanisms of impaired or preserved visual cognition have not been probed from direct function-execution conditions and few works have observed it on whole-brain dynamic networks. We used high-resolution electroencephalogram recordings from 25 patients with brain tumors to track the dynamical patterns of functional reorganization in visual processing tasks with multilevel complexity. By comparing with 24 healthy controls, increased cortical responsiveness as functional compensation was identified in the early phase of processing, which was highly localized to the visual cortex and functional networks and less relevant to the tumor position. Besides, a spreading wide enhancement in whole-brain functional connectivity was elicited by the visual word-recognition task. Enhanced early rapid-onset cortical compensation in the local functional networks may contribute to largely preserved basic vision functions, and higher-cognitive tasks are vulnerable to impairment but with high sensitivity of functional plasticity being elicited.

Altered resting functional connectivity patterns associated with problematic substance use and substance use disorders during adolescence.

BACKGROUND: Adolescence is typified by increasing rates of substance use and the development of substance use disorders (SUD). Aberrant connectivity between cortical regions involved in executive control, and subcortical regions has been suggested to be associated with SUD and problematic substance use among adolescents. Few studies, however, have investigated system-level or whole-brain functional connectivity (FC) in order to test this hypothesis. METHODS: In a sample of 114 adolescents (mean age = 17.62 years, SD = 1.23, 61F) from the community, the present study used resting-state functional magnetic resonance imaging and independent component analysis to study executive control-subcortical network (ECN-SCN) coupling in adolescent SUD (n=18) and problematic substance use (n=34). In addition, whole-brain FC analyses were also conducted. RESULTS: Problematic substance use, but not SUD, was associated with increased negative ECN-SCN coupling (p = 0.026). The whole-brain FC analysis showed insula-associated hypoconnectivity in the SUD group (p = 0.037), which was negatively correlated with frequency of substance use. CONCLUSIONS: Findings implicate different neural circuitry underlying adolescent SUD versus problematic use. Greater negative coupling between the SCN and ECN in adolescents with problematic substance use could underlie risk for future development of SUD or other mental health problems. Although we cannot infer directionality, hypoconnectivity within the insula in adolescents with SUD may indicate addiction-related alterations in interoceptive awareness or impairments in decision-making.