RESUMEN
A captive marmoset developed metastatic endometrioid carcinoma (EnC), a rare uterine tumor in non-human primates (NHPs). The neoplasm showed marked microscopical malignant and tubulopapillary aspects, immunopositivity for pan-cytokeratin, CK7, estrogen receptor, and a high mitotic index (Ki-67). These features may contribute to the diagnosis and therapeutics of EnC in NHPs.
Asunto(s)
Callithrix , Carcinoma Endometrioide , Enfermedades de los Monos , Animales , Femenino , Carcinoma Endometrioide/veterinaria , Carcinoma Endometrioide/patología , Carcinoma Endometrioide/diagnóstico , Enfermedades de los Monos/patología , Enfermedades de los Monos/diagnóstico , Neoplasias Uterinas/veterinaria , Neoplasias Uterinas/patología , Neoplasias Uterinas/diagnósticoRESUMEN
Primary female reproductive neoplasms in Platyrrhines species are few reported. We present the gross, histological, and immunohistochemical findings of metastatic endometrioid carcinoma in the uterus, urinary bladder, jejunum, and rectum of a Leontopithecus sp. The neoplastic endometrial cells expressed strong cytoplasmic immunolabeling of cytokeratin 7.
Asunto(s)
Carcinoma Endometrioide , Neoplasias Endometriales , Leontopithecus , Animales , Femenino , Carcinoma Endometrioide/veterinaria , Carcinoma Endometrioide/patología , Carcinoma Endometrioide/secundario , Neoplasias Endometriales/patología , Neoplasias Endometriales/veterinaria , Inmunohistoquímica/veterinaria , Útero/patologíaRESUMEN
Twelve spontaneous ovarian tumors were found in the Southwest Foundation for Biomedical Research baboon colony. These included four granulosa cell tumors, three teratomas, two endometrioid carcinomas, one seromucinous cystadenofibroma, a cystic papillary adenocarcinoma, and an ovarian carcinoma. Age was a pre-disposing factor. With one exception, the tumors of surface epithelial- and sex cordstromal origin occurred in baboons over 17 years of age. The exceptional animal was 7 years of age when a malignant granulosa cell tumor with Sertoli cell differentiation was identified. The two endometrioid tumors, which were found in 17- and 30-year-old animals, were both associated with endometriosis. In contrast, the teratomas, which are tumors of germ cell origin, were found in younger animals, i.e. 17 years of age or younger. One case of an ovarian carcinoma with metastases was observed in a 6-month-old infant. Cases of spontaneous ovarian tumors from the literature are reviewed.