Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats.

Giorgino, F; Logoluso, F; Davalli, A M; Napoli, R; Laviola, L; Hirshman, M F; Horton, E S; Weir, G C; Smith, R J

Giorgino, F; Logoluso, F; Davalli, A M; Napoli, R; Laviola, L; Hirshman, M F; Horton, E S; Weir, G C; Smith, R J.

Affiliation

Giorgino F; Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche, University of Bari School of Medicine, Italy. giorginf@tin.it

Diabetes ; 48(4): 801-12, 1999 Apr.

Article in En | MEDLINE | ID: mdl-10102697

Subject(s)

Diabetes Mellitus, Experimental/surgery; Islets of Langerhans Transplantation; Muscle, Skeletal/metabolism; Myocardium/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Receptor, Insulin/metabolism; Tyrosine/metabolism; Animals; Insulin/physiology; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Phosphoproteins/metabolism; Phosphorylation; Rats; Rats, Inbred Lew; Signal Transduction/physiology

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Database: MEDLINE Main subject: Tyrosine / Receptor, Insulin / Islets of Langerhans Transplantation / Muscle, Skeletal / Phosphatidylinositol 3-Kinases / Diabetes Mellitus, Experimental / Myocardium Limits: Animals Language: En Year: 1999 Type: Article

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