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Keratinocyte growth factor ameliorates dextran sodium sulfate colitis in mice.
Egger, B; Procaccino, F; Sarosi, I; Tolmos, J; Büchler, M W; Eysselein, V E.
Affiliation
  • Egger B; Harbor-UCLA Medical Center, Division of Gastroenterology, Torrance, California 90502, USA.
Dig Dis Sci ; 44(4): 836-44, 1999 Apr.
Article in En | MEDLINE | ID: mdl-10219846
ABSTRACT
Keratinocyte growth factor (KGF) is emerging as an important mediator of mucosal defense and repair in the colon. The aim of the present study was to evaluate and further characterize the effects of exogenous KGF administration utilizing the dextran sodium sulfate (DSS) model of colitis in mice. Colitis was induced via oral administration of DSS (5 g/100 ml) to Balb/c mice for eight days. Intraperitoneal administration of KGF (5 mg/kg, once daily) or vehicle (VEH) was initiated 1 hr prior to the induction of the colitis (N = 10, each group). Mucosal injury of the entire colon was histologically assessed and graded. An approximately fourfold reduction in the crypt damage score was noted in the KGF group when compared to controls (VEH) (2.8 +/- 1.03 and 11.4 +/- 0.78, respectively). The significant reduction of mucosal injury in KGF treated mice confirms that KGF is a key mediator maintaining the integrity of the colonic mucosa.
Subject(s)
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Database: MEDLINE Main subject: Colitis, Ulcerative / Growth Substances / Fibroblast Growth Factors / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals Language: En Year: 1999 Type: Article
Search on Google
Database: MEDLINE Main subject: Colitis, Ulcerative / Growth Substances / Fibroblast Growth Factors / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals Language: En Year: 1999 Type: Article