Intrapulmonary tumor necrosis factor gene therapy increases bacterial clearance and survival in murine gram-negative pneumonia.

Standiford, T J; Wilkowski, J M; Sisson, T H; Hattori, N; Mehrad, B; Bucknell, K A; Moore, T A

Standiford, T J; Wilkowski, J M; Sisson, T H; Hattori, N; Mehrad, B; Bucknell, K A; Moore, T A.

Affiliation

Standiford TJ; Department of Medicine, The University of Michigan Medical School, Ann Arbor 48109, USA.

Hum Gene Ther ; 10(6): 899-909, 1999 Apr 10.

Article in En | MEDLINE | ID: mdl-10223724

Subject(s)

Genetic Therapy; Klebsiella pneumoniae/isolation & purification; Pneumonia, Bacterial/therapy; Tumor Necrosis Factor-alpha/genetics; Adenoviridae/genetics; Animals; Bronchoalveolar Lavage Fluid; DNA, Complementary; Female; Genetic Vectors; Immunohistochemistry; Lung/metabolism; Mice; Mice, Inbred CBA; Pneumonia, Bacterial/microbiology; Survival Rate; Transgenes

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PubMed Links

Database: MEDLINE Main subject: Genetic Therapy / Tumor Necrosis Factor-alpha / Pneumonia, Bacterial / Klebsiella pneumoniae Limits: Animals Language: En Year: 1999 Type: Article

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