Liver disease as primary manifestation of multiple myeloma in a young man.
Leuk Res
; 23(4): 403-5, 1999 Apr.
Article
in En
| MEDLINE
| ID: mdl-10229327
ABSTRACT
We report a 27-year-old man who presented with fatigue, moderate weight loss and progressive abdominal distension as primary manifestations of a light-chain multiple myeloma (MM). Liver scan showed an enlarged liver with multiple low attenuation areas. Liver biopsy revealed sinusoidal infiltration by small size cells identified as Kappa light chain-producing primitive plasma cells by immunohistochemistry. The patient responded to three courses of EDAP. Subsequently he received intensive therapy with busulfan/melfalan and a peripheral blood stem cell transplantation enriched for CD34+ cells from his HLA-identical brother. No acute graft-versus-host disease was detected. Now, 12 months after transplant, the patient is asymptomatic.
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Database:
MEDLINE
Main subject:
Liver Diseases
/
Multiple Myeloma
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Year:
1999
Type:
Article