Structure-based design of non-peptide, carbohydrazide-based cathepsin K inhibitors.

Thompson, S K; Halbert, S M; DesJarlais, R L; Tomaszek, T A; Levy, M A; Tew, D G; Ijames, C F; Veber, D F

Thompson, S K; Halbert, S M; DesJarlais, R L; Tomaszek, T A; Levy, M A; Tew, D G; Ijames, C F; Veber, D F.

Affiliation

Thompson SK; Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA. Scott_K_Thompson@sbphrd.com

Bioorg Med Chem ; 7(4): 599-605, 1999 Apr.

Article in En | MEDLINE | ID: mdl-10353639

Subject(s)

Cathepsins/antagonists & inhibitors; Drug Design; Cathepsin K; Kinetics; Models, Molecular

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Database: MEDLINE Main subject: Drug Design / Cathepsins Type of study: Prognostic_studies Language: En Year: 1999 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Drug Design / Cathepsins Type of study: Prognostic_studies Language: En Year: 1999 Type: Article