Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures.
Brain Res
; 842(1): 239-42, 1999 Sep 18.
Article
in En
| MEDLINE
| ID: mdl-10526118
ABSTRACT
Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seizures in several models of epilepsy. Using in situ hybridization, we demonstrate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) but not vesicular monoamine transporter 2 (VMAT2) mRNA levels are transiently elevated in LC neurons following kainic acid-induced status epilepticus. These increases of TH and NET mRNAs and presumably of the proteins themselves might enhance synthesis and reuptake of NE postictally.
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Database:
MEDLINE
Main subject:
Membrane Transport Proteins
/
Seizures
/
Tyrosine 3-Monooxygenase
/
Neuropeptides
/
RNA, Messenger
/
Carrier Proteins
/
Norepinephrine
/
Excitatory Amino Acid Agonists
/
Symporters
/
Kainic Acid
Limits:
Animals
Language:
En
Year:
1999
Type:
Article