Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.

Fedde, K N; Blair, L; Silverstein, J; Coburn, S P; Ryan, L M; Weinstein, R S; Waymire, K; Narisawa, S; Millán, J L; MacGregor, G R; Whyte, M P

Fedde, K N; Blair, L; Silverstein, J; Coburn, S P; Ryan, L M; Weinstein, R S; Waymire, K; Narisawa, S; Millán, J L; MacGregor, G R; Whyte, M P.

Affiliation

Fedde KN; Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, Missouri, USA.

J Bone Miner Res ; 14(12): 2015-26, 1999 Dec.

Article in En | MEDLINE | ID: mdl-10620060

Subject(s)

Alkaline Phosphatase/genetics; Hypophosphatasia/genetics; Age Factors; Alkaline Phosphatase/blood; Animals; Animals, Newborn; Body Weight/genetics; Disease Models, Animal; Heterozygote; Hindlimb/diagnostic imaging; Hindlimb/growth & development; Histocytochemistry; Homozygote; Hypophosphatasia/diagnostic imaging; Hypophosphatasia/metabolism; Mice; Mice, Knockout; Phosphates/urine; Phosphatidylethanolamines/urine; Pyridoxal Phosphate/blood; Radiography; Tibia/diagnostic imaging; Tibia/growth & development

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Full text: 1 Database: MEDLINE Main subject: Alkaline Phosphatase / Hypophosphatasia Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Year: 1999 Type: Article

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