The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.
Nat Med
; 6(4): 429-34, 2000 Apr.
Article
in En
| MEDLINE
| ID: mdl-10742150
ABSTRACT
Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart failure and sudden death. We show here that the sarcoma (Src) family kinase Lck (p56lck) is required for efficient CVB3 replication in T-cell lines and for viral replication and persistence in vivo. Whereas infection of wild-type mice with human pathogenic CVB3 caused acute and very severe myocarditis, meningitis, hepatitis, pancreatitis and dilated cardiomyopathy, mice lacking the p56lck gene were completely protected from CVB3-induced acute pathogenicity and chronic heart disease. These data identify a previously unknown function of Src family kinases and indicate that p56lck is the essential host factor that controls the replication and pathogenicity of CVB3.
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Database:
MEDLINE
Main subject:
Cardiomyopathy, Dilated
/
Enterovirus B, Human
/
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
/
Coxsackievirus Infections
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Year:
2000
Type:
Article