Novel cytotoxic diterpenes from Casearia arborea.

Beutler, J A; McCall, K L; Herbert, K; Herald, D L; Pettit, G R; Johnson, T; Shoemaker, R H; Boyd, M R

Beutler, J A; McCall, K L; Herbert, K; Herald, D L; Pettit, G R; Johnson, T; Shoemaker, R H; Boyd, M R.

Affiliation

Beutler JA; Laboratory of Drug Discovery Research & Development, Developmental Therapeutics Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute-FCRDC, Bldg. 1052, Rm. 121, Frederick, Maryland 21702-1201, USA.

J Nat Prod ; 63(5): 657-61, 2000 May.

Article in En | MEDLINE | ID: mdl-10843580

ABSTRACT

ABSTRACT

Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.

Subject(s)

Antineoplastic Agents, Phytogenic/isolation & purification; Diterpenes/isolation & purification; Plants, Medicinal/chemistry; Antineoplastic Agents, Phytogenic/pharmacology; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Diterpenes/pharmacology; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Plants, Medicinal / Diterpenes / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Year: 2000 Type: Article

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Plants, Medicinal / Diterpenes / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Year: 2000 Type: Article