Assessment of the percutaneous absorption of trichloroethylene in rats and humans using MS/MS real-time breath analysis and physiologically based pharmacokinetic modeling.

Poet, T S; Corley, R A; Thrall, K D; Edwards, J A; Tanojo, H; Weitz, K K; Hui, X; Maibach, H I; Wester, R C

Poet, T S; Corley, R A; Thrall, K D; Edwards, J A; Tanojo, H; Weitz, K K; Hui, X; Maibach, H I; Wester, R C.

Affiliation

Poet TS; Chemical Dosimetry, Battelle, Pacific Northwest Division, Post Office Box 999, MSIN P7-59, Richland, Washington 99352, USA. torka.poet@pnl.gov

Toxicol Sci ; 56(1): 61-72, 2000 Jul.

Article in En | MEDLINE | ID: mdl-10869454

Subject(s)

Skin Absorption; Skin/metabolism; Trichloroethylene/pharmacokinetics; Administration, Cutaneous; Animals; Biological Availability; Breath Tests/methods; Female; Humans; Male; Mass Spectrometry; Models, Biological; Rats; Rats, Inbred F344; Trichloroethylene/administration & dosage

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PubMed Links

Database: MEDLINE Main subject: Skin / Skin Absorption / Trichloroethylene Limits: Animals / Female / Humans / Male Language: En Year: 2000 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Skin / Skin Absorption / Trichloroethylene Limits: Animals / Female / Humans / Male Language: En Year: 2000 Type: Article