A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.

Boyd, M T; Vlatkovic, N; Haines, D S

Boyd, M T; Vlatkovic, N; Haines, D S.

Affiliation

Boyd MT; Division of Hematology/Oncology, MCP Hahnemann University Cancer Center, Philadelphia, Pennsylvania 19102, USA. mboyd@liverpool.ac.uk

J Biol Chem ; 275(41): 31883-90, 2000 Oct 13.

Article in En | MEDLINE | ID: mdl-10906133

Subject(s)

Carrier Proteins/antagonists & inhibitors; Carrier Proteins/metabolism; G1 Phase; Nuclear Proteins; Proto-Oncogene Proteins/metabolism; Amino Acid Sequence; Animals; Carrier Proteins/chemistry; Carrier Proteins/genetics; Cell Division; Flow Cytometry; Gene Expression Profiling; Growth Inhibitors/antagonists & inhibitors; Growth Inhibitors/chemistry; Growth Inhibitors/genetics; Growth Inhibitors/metabolism; Humans; Mice; Molecular Sequence Data; Protein Binding; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-mdm2; Sequence Alignment; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53/physiology; Two-Hybrid System Techniques

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PubMed Links

Database: MEDLINE Main subject: Nuclear Proteins / Carrier Proteins / G1 Phase / Proto-Oncogene Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2000 Type: Article

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