3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator.

Djuric, S W; BaMaung, N Y; Basha, A; Liu, H; Luly, J R; Madar, D J; Sciotti, R J; Tu, N P; Wagenaar, F L; Wiedeman, P E; Zhou, X; Ballaron, S; Bauch, J; Chen, Y W; Chiou, X G; Fey, T; Gauvin, D; Gubbins, E; Hsieh, G C; Marsh, K C; Mollison, K W; Pong, M; Shaughnessy, T K; Sheets, M P; Smith, M; Trevillyan, J M; Warrior, U; Wegner, C D; Carter, G W

Djuric, S W; BaMaung, N Y; Basha, A; Liu, H; Luly, J R; Madar, D J; Sciotti, R J; Tu, N P; Wagenaar, F L; Wiedeman, P E; Zhou, X; Ballaron, S; Bauch, J; Chen, Y W; Chiou, X G; Fey, T; Gauvin, D; Gubbins, E; Hsieh, G C; Marsh, K C; Mollison, K W; Pong, M; Shaughnessy, T K; Sheets, M P; Smith, M; Trevillyan, J M; Warrior, U; Wegner, C D; Carter, G W.

Affiliation

Djuric SW; Immunological Diseases Research, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064-6217, USA. stevan.w.djuric@abbott.com

J Med Chem ; 43(16): 2975-81, 2000 Aug 10.

Article in En | MEDLINE | ID: mdl-10956206

Subject(s)

Chemokines, CC; DNA-Binding Proteins/metabolism; Nuclear Proteins; Protein Synthesis Inhibitors/chemical synthesis; Pyrazoles/chemical synthesis; Transcription Factors/metabolism; Animals; Asthma/drug therapy; Cell Division; Chemokine CCL11; Combinatorial Chemistry Techniques; Cyclosporine/pharmacology; Cytokines/antagonists & inhibitors; Cytokines/biosynthesis; Genes, Reporter; Haplorhini; Humans; Immunosuppressive Agents/chemical synthesis; Immunosuppressive Agents/chemistry; Immunosuppressive Agents/pharmacology; In Vitro Techniques; Interleukin-2/antagonists & inhibitors; Interleukin-2/biosynthesis; Interleukin-4/antagonists & inhibitors; Interleukin-4/biosynthesis; Interleukin-5/antagonists & inhibitors; Interleukin-5/biosynthesis; Interleukin-8/antagonists & inhibitors; Interleukin-8/biosynthesis; Jurkat Cells; Leukocytes, Mononuclear/cytology; Leukocytes, Mononuclear/drug effects; Luciferases/genetics; NFATC Transcription Factors; Protein Synthesis Inhibitors/chemistry; Protein Synthesis Inhibitors/pharmacology; Pyrazoles/chemistry; Pyrazoles/pharmacology; Rats

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Database: MEDLINE Main subject: Pyrazoles / Transcription Factors / Nuclear Proteins / Protein Synthesis Inhibitors / Chemokines, CC / DNA-Binding Proteins Type of study: Prognostic_studies Language: En Year: 2000 Type: Article

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