Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model.

Huang, J; Driscoll, E M; Gonzales, M L; Park, A M; Lucchesi, B R

Huang, J; Driscoll, E M; Gonzales, M L; Park, A M; Lucchesi, B R.

Affiliation

Huang J; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0632, USA.

J Pharmacol Exp Ther ; 295(2): 492-9, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11046080

Subject(s)

Adenosine Monophosphate/analogs & derivatives; Adenosine Monophosphate/therapeutic use; Carotid Artery Thrombosis/prevention & control; Membrane Proteins; Platelet Aggregation Inhibitors/therapeutic use; Purinergic P2 Receptor Antagonists; Adenosine Diphosphate/antagonists & inhibitors; Adenosine Diphosphate/toxicity; Animals; Arterial Occlusive Diseases/etiology; Arterial Occlusive Diseases/prevention & control; Bleeding Time; Blood Flow Velocity/drug effects; Blood Platelets/drug effects; Carotid Arteries/drug effects; Carotid Artery Thrombosis/etiology; Disease Models, Animal; Dogs; Female; Hemodynamics/drug effects; Injections, Intravenous; Male; Platelet Aggregation/drug effects; Receptors, Purinergic P2Y12; Tunica Intima/injuries

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Platelet Aggregation Inhibitors / Carotid Artery Thrombosis / Adenosine Monophosphate / Purinergic P2 Receptor Antagonists / Membrane Proteins Type of study: Etiology_studies Limits: Animals Language: En Year: 2000 Type: Article

Search on Google

XML

PubMed Links