A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid.

Ploeger, B; Mensinga, T; Sips, A; Deerenberg, C; Meulenbelt, J; DeJongh, J

Ploeger, B; Mensinga, T; Sips, A; Deerenberg, C; Meulenbelt, J; DeJongh, J.

Affiliation

Ploeger B; Research Institute of Toxicology (RITOX), Utrecht, 3508 TD, The Netherlands.

Toxicol Appl Pharmacol ; 170(1): 46-55, 2001 Jan 01.

Article in En | MEDLINE | ID: mdl-11141355

Subject(s)

Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/pharmacokinetics; Glycyrrhetinic Acid/pharmacology; Glycyrrhetinic Acid/pharmacokinetics; Hydroxysteroid Dehydrogenases/antagonists & inhibitors; 11-beta-Hydroxysteroid Dehydrogenases; Adult; Algorithms; Cortisone/urine; Humans; Hydrocortisone/urine; Male; Nonlinear Dynamics; Population; Reproducibility of Results

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Database: MEDLINE Main subject: Enzyme Inhibitors / Glycyrrhetinic Acid / Hydroxysteroid Dehydrogenases Type of study: Prognostic_studies Limits: Adult / Humans / Male Language: En Year: 2001 Type: Article

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