Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating.

Binder, E B; Kinkead, B; Owens, M J; Kilts, C D; Nemeroff, C B

Binder, E B; Kinkead, B; Owens, M J; Kilts, C D; Nemeroff, C B.

Affiliation

Binder EB; Max Planck Institute for Psychiatry, 80804 Munich, Germany.

J Neurosci ; 21(2): 601-8, 2001 Jan 15.

Article in En | MEDLINE | ID: mdl-11160439

Subject(s)

Adamantane/analogs & derivatives; Antipsychotic Agents/pharmacology; Neurotensin/metabolism; Psychomotor Performance/drug effects; Schizophrenia/metabolism; Synaptic Transmission/drug effects; Acoustic Stimulation; Adamantane/pharmacology; Animals; Behavior, Animal/drug effects; Brain/metabolism; Brain/pathology; Conditioning, Classical/drug effects; Dibenzothiazepines/pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Haloperidol/pharmacology; Imidazoles/pharmacology; Inhibition, Psychological; Neurotensin/genetics; Photic Stimulation; Quetiapine Fumarate; RNA, Messenger/metabolism; Rats; Rats, Long-Evans; Reaction Time/drug effects; Receptors, Neurotensin/agonists; Receptors, Neurotensin/antagonists & inhibitors; Receptors, Neurotensin/metabolism; Reflex, Startle/drug effects; Social Isolation

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Full text: 1 Database: MEDLINE Main subject: Psychomotor Performance / Schizophrenia / Antipsychotic Agents / Neurotensin / Adamantane / Synaptic Transmission Type of study: Prognostic_studies Limits: Animals Language: En Year: 2001 Type: Article

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