New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.

Vlieghe, P; Bihel, F; Clerc, T; Pannecouque, C; Witvrouw, M; De Clercq, E; Salles, J P; Chermann, J C; Kraus, J L

Vlieghe, P; Bihel, F; Clerc, T; Pannecouque, C; Witvrouw, M; De Clercq, E; Salles, J P; Chermann, J C; Kraus, J L.

Affiliation

Vlieghe P; Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, 163 avenue de Luminy, case 901, 13288 Marseille Cedex 9, France.

J Med Chem ; 44(5): 777-86, 2001 Mar 01.

Article in En | MEDLINE | ID: mdl-11262088

Subject(s)

Anti-HIV Agents/chemical synthesis; Carbamates/chemical synthesis; Prodrugs/chemical synthesis; Zidovudine/chemical synthesis; Anti-HIV Agents/chemistry; Anti-HIV Agents/metabolism; Anti-HIV Agents/pharmacology; Carbamates/chemistry; Carbamates/metabolism; Carbamates/pharmacology; Cell Line; Drug Stability; HIV-1/drug effects; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Prodrugs/chemistry; Prodrugs/metabolism; Prodrugs/pharmacology; Structure-Activity Relationship; Zidovudine/analogs & derivatives; Zidovudine/chemistry; Zidovudine/metabolism; Zidovudine/pharmacology

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Database: MEDLINE Main subject: Carbamates / Prodrugs / Zidovudine / Anti-HIV Agents Limits: Humans Language: En Year: 2001 Type: Article

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Carbamates / Prodrugs / Zidovudine / Anti-HIV Agents Limits: Humans Language: En Year: 2001 Type: Article