Birth weight and childhood onset type 1 diabetes: population based cohort study.
BMJ
; 322(7291): 889-92, 2001 Apr 14.
Article
in En
| MEDLINE
| ID: mdl-11302899
ABSTRACT
OBJECTIVE:
To assess the associations between birth weight or gestational age and risk of type 1 diabetes.DESIGN:
Population based cohort study by record linkage of the medical birth registry and the National Childhood Diabetes Registry.SETTING:
Two national registries in Norway.PARTICIPANTS:
All live births in Norway between 1974 and 1998 (1 382 602 individuals) contributed a maximum of 15 years of observation, a total of 8 184 994 person years of observation in the period 1989 to 1998. 1824 children with type 1 diabetes were diagnosed between 1989 and 1998. MAIN OUTCOMEMEASURES:
Estimates of rate ratios with 95% confidence intervals for type 1 diabetes from Poisson regression analyses.RESULTS:
The incidence rate of type 1 diabetes increased almost linearly with birth weight. The rate ratio for children with birth weights 4500 g or more compared with those with birth weights less than 2000 g was 2.21 (95% confidence interval 1.24 to 3.94), test for trend P=0.0001. There was no significant association between gestational age and type 1 diabetes. The results persisted after adjustment for maternal diabetes and other potential confounders.CONCLUSION:
There is a relatively weak but significant association between birth weight and increased risk of type 1 diabetes consistent over a wide range of birth weights.
Full text:
1
Database:
MEDLINE
Main subject:
Birth Weight
/
Diabetes Mellitus, Type 1
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Europa
Language:
En
Year:
2001
Type:
Article