Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.

Cuello, M; Ettenberg, S A; Clark, A S; Keane, M M; Posner, R H; Nau, M M; Dennis, P A; Lipkowitz, S

Cuello, M; Ettenberg, S A; Clark, A S; Keane, M M; Posner, R H; Nau, M M; Dennis, P A; Lipkowitz, S.

Affiliation

Cuello M; Genetics Department, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20889, USA.

Cancer Res ; 61(12): 4892-900, 2001 Jun 15.

Article in En | MEDLINE | ID: mdl-11406568

Subject(s)

Antibodies, Monoclonal/pharmacology; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Breast Neoplasms/pathology; Membrane Glycoproteins/pharmacology; Ovarian Neoplasms/pathology; Protein Serine-Threonine Kinases; Receptor, ErbB-2/biosynthesis; Tumor Necrosis Factor-alpha/pharmacology; Antibodies, Monoclonal, Humanized; Apoptosis/physiology; Apoptosis Regulatory Proteins; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Down-Regulation/drug effects; Drug Synergism; Female; Humans; Membrane Glycoproteins/genetics; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/metabolism; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2/genetics; Receptor, ErbB-2/physiology; Recombinant Fusion Proteins/pharmacology; TNF-Related Apoptosis-Inducing Ligand; Trastuzumab; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha/genetics

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Ovarian Neoplasms / Breast Neoplasms / Membrane Glycoproteins / Tumor Necrosis Factor-alpha / Protein Serine-Threonine Kinases / Apoptosis / Receptor, ErbB-2 / Antibodies, Monoclonal / Antineoplastic Agents Limits: Female / Humans Language: En Year: 2001 Type: Article

Search on Google

XML

PubMed Links