Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm.

Berra, E; Roux, D; Richard, D E; Pouysségur, J

Berra, E; Roux, D; Richard, D E; Pouysségur, J.

Affiliation

Berra E; Institute of Signalling, Developmental Biology and Cancer Research, CNRS-UMR 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose 06189 Nice, France.

EMBO Rep ; 2(7): 615-20, 2001 Jul.

Article in En | MEDLINE | ID: mdl-11454738

Subject(s)

Acetylcysteine/analogs & derivatives; Cell Nucleus/metabolism; Cysteine Endopeptidases/metabolism; Cytoplasm/metabolism; Multienzyme Complexes/metabolism; Transcription Factors/metabolism; Acetylcysteine/pharmacology; Active Transport, Cell Nucleus/drug effects; Active Transport, Cell Nucleus/physiology; Antibiotics, Antineoplastic/pharmacology; Cell Fractionation; Cell Hypoxia/physiology; Cell Line; Cysteine Endopeptidases/drug effects; Cysteine Proteinase Inhibitors/pharmacology; Fatty Acids, Unsaturated/pharmacology; Humans; Immunoblotting; Multienzyme Complexes/drug effects; Oxygen/metabolism; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Sodium-Hydrogen Exchangers/genetics; Transfection

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Full text: 1 Database: MEDLINE Main subject: Acetylcysteine / Transcription Factors / Cysteine Endopeptidases / Cell Nucleus / Cytoplasm / Multienzyme Complexes Limits: Humans Language: En Year: 2001 Type: Article

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