A new triterpenoidal saponin from Ixeris sonchifolia and its cytotoxic activity.

Feng, X Z; Dong, M; Xu, S X

Feng, X Z; Dong, M; Xu, S X.

Affiliation

Feng XZ; Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang, P.R. China.

Pharmazie ; 56(8): 663-4, 2001 Aug.

Article in En | MEDLINE | ID: mdl-11534348

ABSTRACT

ABSTRACT

A new triterpenoidal saponin, echinocystic acid 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranoside (1), was isolated from Ixeris sonchifolia. Its structure was elucidated on the basis of full spectral data analysis and chemical methods. The cytotoxic activity of compound 1 was evaluated using the tumor cell lines of A375, Hela, and L929 in vitro.

Subject(s)

Antineoplastic Agents, Phytogenic/isolation & purification; Oleanolic Acid/analogs & derivatives; Plants, Medicinal/chemistry; Saponins/isolation & purification; Triterpenes/isolation & purification; Antineoplastic Agents, Phytogenic/pharmacology; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Saponins/pharmacology; Spectrometry, Mass, Electrospray Ionization; Triterpenes/pharmacology; Tumor Cells, Cultured

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Oleanolic Acid / Plants, Medicinal / Saponins / Triterpenes / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Year: 2001 Type: Article

Search on Google

XML

PubMed Links