The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease.
Arch Neurol
; 58(9): 1425-8, 2001 Sep.
Article
in En
| MEDLINE
| ID: mdl-11559314
ABSTRACT
BACKGROUND:
Aggressive behavior in Alzheimer disease (AD) has been linked to dysfunction of serotonin neurotransmission. Homozygosity for the long variant (*L) of an identified biallelic polymorphism of the serotonin transporter promoter region (5-HTTPR) is associated with increased expression of the transporter protein and increased speed of response to serotonin reuptake inhibitor treatment.OBJECTIVE:
To determine whether the *L/*L genotype and the *L allele are associated with an increased risk of aggressive symptoms in patients with AD.DESIGN:
Case-control study.SETTING:
University hospital geriatric psychiatry inpatient program and Alzheimer disease research center.SUBJECTS:
Fifty-eight patients with AD with a history of aggressive behavior and 79 never-aggressive patients with AD with comparable severity of cognitive impairment. MAIN OUTCOMEMEASURES:
The 5-HTTPR genotype and allele frequency.RESULTS:
The *L/*L genotype was significantly associated with aggression in patients with AD (odds ratio, 2.8; 95% confidence interval, 1.2-6.5). Similar results were obtained for *L allele frequency.CONCLUSION:
The 5-HTTPR*L allele and *L/*L genotype may predispose patients with AD to develop aggressive behavior.
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Database:
MEDLINE
Main subject:
Membrane Transport Proteins
/
Polymorphism, Genetic
/
Membrane Glycoproteins
/
Carrier Proteins
/
Promoter Regions, Genetic
/
Aggression
/
Alzheimer Disease
/
Nerve Tissue Proteins
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Year:
2001
Type:
Article