Multimerization potential of the cytoplasmic domain of the human cytomegalovirus glycoprotein B.
FEBS Lett
; 506(2): 113-6, 2001 Oct 05.
Article
in En
| MEDLINE
| ID: mdl-11591382
ABSTRACT
In the present study the coding sequence of the cytoplasmic tail of the human cytomegalovirus glycoprotein B (gB) was expressed. The secondary structure of the purified recombinant protein was analyzed by circular dichroism, and the quaternary structure was investigated by gel permeation chromatography, and electron microscopy. Our data indicate that the cytoplasmic gB domain contains alpha-helix structures and assembles into tetramers, suggesting that the authentic gB may represent a homotetramer.
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Database:
MEDLINE
Main subject:
Viral Envelope Proteins
/
Cytomegalovirus
Limits:
Humans
Language:
En
Year:
2001
Type:
Article