Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways.

Doshi, P D; Giri, J G; Abegg, A L; Favara, J P; Huynh, M S; Kahn, L E; Minnerly, J C; Pegg, L E; Villani-Price, D; Siegel, N R; Staten, N R; Thomas, J W; McKearn, J P; Smith, W G

Doshi, P D; Giri, J G; Abegg, A L; Favara, J P; Huynh, M S; Kahn, L E; Minnerly, J C; Pegg, L E; Villani-Price, D; Siegel, N R; Staten, N R; Thomas, J W; McKearn, J P; Smith, W G.

Affiliation

Doshi PD; Pharmacia Discovery Research, Chesterfield, Mo. 63198, USA. parul.doshi@pharmacia.com

Exp Hematol ; 29(10): 1177-84, 2001 Oct.

Article in En | MEDLINE | ID: mdl-11602319

Subject(s)

Growth Substances/pharmacology; Hematopoietic Stem Cells/cytology; Megakaryocytes/immunology; Milk Proteins; Neoplasm Proteins; Signal Transduction/immunology; Thrombopoietin/physiology; Amino Acid Sequence; Animals; Blood Platelets/cytology; Blood Platelets/drug effects; Blood Platelets/physiology; Bone Marrow Cells/cytology; Cell Division/drug effects; Cell Line; Cells, Cultured; Cloning, Molecular; DNA-Binding Proteins/metabolism; Female; Hematopoietic Stem Cells/drug effects; Humans; Interleukin-3; Janus Kinase 2; Macaca mulatta; Megakaryocytes/drug effects; Molecular Sequence Data; Phosphorylation; Phosphotyrosine/analysis; Phosphotyrosine/metabolism; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins/physiology; Receptors, Cytokine/metabolism; Receptors, Interleukin-3/physiology; Receptors, Thrombopoietin; Recombinant Fusion Proteins/pharmacology; STAT5 Transcription Factor; Signal Transduction/drug effects; Trans-Activators/metabolism; Transfection

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Database: MEDLINE Main subject: Thrombopoietin / Hematopoietic Stem Cells / Megakaryocytes / Signal Transduction / Growth Substances / Milk Proteins / Neoplasm Proteins Language: En Year: 2001 Type: Article

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